HORMONES IN CAUSE AND TREATMENT OF AFFECTIVE DISORDERS

激素导致情感障碍和治疗

• 批准号: 3076051
• 负责人: ARTHUR J. PRANGE
• 金额: $ 9.98万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-15 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3076051
• 关键词: Graves disease; alcoholic beverage consumption; antidepressants; brain; calcium metabolism; child (0-11); electroconvulsive therapy; endocrine disorder diagnosis; hormone regulation /control mechanism; human subject; hyperparathyroidism; hypoparathyroidism; laboratory rat; learning disorders; mental disorder chemotherapy; mental disorders; mood disorders; parathyroid disorder; phenobarbital; psychological tests; psychopharmacology; psychotropic drugs; radionuclide therapy; thyroid function; thyrotropin releasing hormone; triiodothyronine

All aspects of the proposed work pertain to the thyroid axis,providing thematic unity. Operational cohesion is provided by the participation and leadership of the applicant, by his experience, and by his commitment to mentorship. Clinical studies are guided in part by the observation that changes in thyroid status,especially toward hypothyroidism, are common and by the notion that such changes, even when slight, may impair CNS function. Study One is addressed to patients with Graves' disease, who are assessed in several ways when hyperthyroid (from illness), when hypothyroid (from radioiodine treatment), and when euthyroid (from hormone replacement). In Study Two the notions are examined: that patients coming for ECT may have been inadvertently "selected" for subclinical hypothyroidism; that ECT thus does them "special" damage, because it, like hypothyroidism, impairs memory. Does administered thyroid hormone protect them? Study Three goes directly to the question of subclinical hypothyroidism. What is its prevalence? Do such patients profit from treatment with a thyroid hormone? Study Four seeks to assess the extent to which TRH will offset effects of common sedatives. In Study Five children with a learning disorder are assessed for the nature and severity of their disorder and for subtle changes in thyroid status. Four animal studies are proposed, each resonating with one or another clinical study. In Study One the role of thyroid hormones in regulating the uptake of calcium by brain neurons is measured. We have found that hypothyroidism reduces depolarization-induced calcium ptake. In Study Two the complex relationships in rats between alcohol intake and thyroid state are examined, including an analog of the now-classical clinical finding, TSH blunting in response to administered TRH. Study Three examines the effects of psychotropic drugs, including common sedatives, on TRH binding in brain. Study Four takes as its dependent variable the uptake by brain neurons of thyroid hormones (see uptake of calcium, above). How do drugs affect it? We have confirmed the finding of Dratman that desmethylimi- pramine reduces thyroxine uptake. Do antidepressants make the brain hypothyroid?

拟议工作的所有方面都与甲状腺轴有关，提供 主题统一。运营凝聚力是通过参与和 申请人的领导力、经验和承诺 指导。 临床研究部分是通过观察变化来指导的 甲状腺状态，尤其是甲状腺功能减退症，很常见，并且 认为这种变化，即使是轻微的，也可能损害中枢神经系统功能。学习 其中一项是针对患有格雷夫斯病的患者，他们接受以下评估： 当甲状腺功能亢进（由于疾病）、当甲状腺功能减退（由于疾病）时，有几种方法 放射性碘治疗），以及甲状腺功能正常时（通过激素替代治疗）。在 研究二检查了这一概念：接受 ECT 的患者可能患有 无意中被“选中”为亚临床甲状腺功能减退症； ECT 因此 对它们造成“特殊”损害，因为它像甲状腺功能减退症一样，损害 记忆。服用甲状腺激素可以保护他们吗？研究三进行 直接讨论亚临床甲状腺功能减退症的问题。它是什么 流行程度？这些患者可以从甲状腺激素治疗中获益吗？ 研究四旨在评估 TRH 将在多大程度上抵消 常见的镇静剂。在研究中，五名患有学习障碍的儿童 评估其疾病的性质和严重程度以及微妙的 甲状腺状态的变化。 提出了四项动物研究，每一项都与一个或另一个产生共鸣 临床研究。在研究一中，甲状腺激素在调节 测量大脑神经元对钙的吸收。我们发现 甲状腺功能减退症会降低去极化引起的钙摄入。在研究二中 大鼠酒精摄入量与甲状腺状态之间的复杂关系 进行了检查，包括现在经典的临床发现的类似物， 对 TRH 的反应导致 TSH 减弱。研究三检验了 精神药物（包括普通镇静剂）对 TRH 结合的影响 在大脑中。研究四将大脑的摄取作为因变量 甲状腺激素神经元（参见上文钙的摄取）。毒品怎么办 影响吗？我们已经证实 Dratman 的发现，去甲基亚胺- 帕明可减少甲状腺素的摄取。抗抑郁药对大脑有影响吗 hypothyroid?