MHCRC-PHYCHOENDOCRINOLOGY: CHILDREN AND ADULTS

该中心的总体目标是建立一个组织 成人和成人主要精神障碍的神经心理内分泌学研究 儿童是心理健康问题的核心。在成人中，这些 包括堕落、躁狂、酗酒、精神分裂症和精神综合症 与肾透析相关；儿童多动症、自闭症和精神疾病 智力迟缓。这些研究的理论基础包括以下原则 神经内分泌学和神经递质生理学原理。 已发现一例垂体反应缺陷(对TRH的TSH反应减弱) 在一些抑郁症患者中，在某些情况下，这种错误与 与疾病状态或这些疾病的高风险特征有关。 对精神病患者和非精神病患者进行平行的垂体腺反应测试，检测TRH。 多动症儿童。相关的神经内分泌研究针对 表现出典型精神症状的肾透析患者。在成人中 精神分裂症在这些轴之间存在分离；TSH反应似乎 与基线皮质醇水平呈正相关。在正常对照组和在 所有其他诊断组之间的关系是负的。被更改的 恋爱关系可能会为精神分裂症提供生化标记物。这个 现代遗传学技术被用来探索两者之间的关系 情感障碍、酒精中毒和多动症候群。的亲属 对表现出促甲状腺激素迟钝的先证者进行测试，以确定生理上的 在家庭中，过错是疾病表现的标志。 基础科学的四个学科涉及到与 临床目标。这些是生物化学，动物神经内分泌学，动物 精神药理学和多肽行为药理学。在这些领域开展工作 澄清了临床起源的问题；它还提供了一些发现，表明 临床干预。 相关临床和基础项目的联系为RICH提供了基础 为几类受训人员提供培训和实践经验。

The overall goal of this Center is to establish an organization for the neuropsychoendocrinological study of the major mental disorders of adults and children which form the hard core of mental health problems. In adults these include depession, mania, alcoholism, schizophrenia and the mental syndromes associated with renal dialysis; in children, hyperkinesis, autism, and mental retardation. The theoretical base for these studies consists of the principles of neuroendocrinology and the principles of neurotransmitter physiology. A pituitary response fault (diminished TSH response to TRH) has been identified in some depressed patients and in some conditions the fault is related to the state of illness or to the trait of being at high risk for these illnesses. Parallel pituitary response testing, with TRH, is carried out in psychotic and hyperkinetic children. Related neuroendocrine investigations are addressed to renal dialysis patients who show characteristic mental syndromes. In adult schizophrenia there is dissociation between these axes; TSH response appears to be positively related to baseline cortisol values. In normal controls and in all other diagnostic groups the relationship is negative. The altered relationships may provide a biochemical marker for schizophrenia. The techniques of modern genetics are used to explore relationships between affective disorders and alcoholism and hyperkinetic syndrome. Relatives of probands who show TSH blunting are tested to establish whether the physiological fault is a marker in families for the demonstration of illness. Four disciplines of basic science are brought to bear on problems relevant to clinical goals. These are biochemistry, animal neuroendocrinology, animal psychopharmacology, and peptide behavioral pharmacology. Work in these areas clarifies problems of clinical origin; it also provides findings that suggest clinical intervention. The nexus of related clinical and basic projects provide a basis for rich training and practical experiences for several categories of trainees.