MHCRC - PSYCHOENDOCRINOLOGY: CHILDREN AND ADULTS

此应用程序寻求对NIMH CRC的延续支持 致力于研究成年人的主要精神障碍和 孩子们。在成年人中，这些包括抑郁，躁狂，酗酒， 惊恐障碍和精神分裂症；在儿童(或年轻人)中， 闭合性头部损伤的后遗症。其理论基础是 建议的研究主要包括以下原则： 神经内分泌学和心理内分泌学；还受雇于 神经递质生理学、药效学原理 动力学、免疫学、神经心理学、生物统计学、生命 历史和计算机科学。 两个内分泌缺陷--TSH对TRH反应降低和 地塞米松后皮质醇抑制失败--提供病灶 用于组织几项拟议的临床研究。其他 概念性主题是：精神分裂症患者的抗精神病药物代谢 患者；抑郁和躁狂患者对以下药物的反应 情感性胆碱能功能改变；5-羟色胺功能改变 精神错乱。两项研究探索了全新的领域：IS 胰岛素的行为效应所必需的低血糖； 考虑到一种诱人的生化关系，如何 氯氮卓酮和TRH对行为和内分泌的影响 功能呢？一项研究，流行病学正在设计中，并计划 在表现上领先于其他人，评估发病率和 边缘甲状腺功能减退症在精神病患者中的意义 住院病人。精神刺激剂对迟发性精神分裂症患者的影响 还将研究闭合性头部损伤的后果。 该中心的四个基础科学部门(其中一个是新的)被捆绑在一起 各种方式相互配合，到五个临床科室(两个 是新的)。几项研究集中在HPT轴上：与 对肽生理学的重要性一般，TRH如何 合成；TRH和胆碱能系统如何在 抑郁模型(波索尔特测试)；甚至轻微 甲状腺功能减退会增加ECT后大鼠的记忆丧失？一些人 动物研究探索多肽作为标记物的用途 肾上腺素能或胆碱能活动及其早期效应 后期HPT和HPA功能分离。其他研究 与我们对精神分裂症日益增长的兴趣产生共鸣：变化 在生殖周期的多巴胺代谢中； 性腺激素对多巴胺能活动的影响；糖尿病对 DA受体起作用。 六个核心小组(三个是新的)支持临床和基础 科学板块，相互促进工作。教学和 该中心的培训活动与 研究活动的深度和广度。

This application seeks continuation support for a NIMH CRC dedicated to the study of major mental disorders of adults and children. In adults these include depression, mania, alcoholism, panic disorder and schizophrenia; in children (or young adults), the sequelae of closed head injury. The theoretical base for the proposed studies consists largely of the principles of neuroendocrinology and psychoendocrinology; also employed are the principles of neurotransmitter physiology, pharmacodynamics and kinetics, immunology, neuropsychology, biostatistics, life history and computer science. Two endocrine faults--the reduced TSH response to TRH and the failure to suppress cortisol after dexamethasone--provide foci for the organization of several proposed clinical studies. Other conceptual themes are: neuroleptic metabolism in schizophrenic patients; responses of depressed and manic patients to drugs that alter cholinergic function; serotonin function in affective disorders. Two studies explore totally new ground: is hypoglycemia necessary to the behavioral effects of insulin; given a tantalizing biochemical relationship, how do chlordiazepoxide and TRH interact on behavior and endocrine function? A study, epidemiologic in design and scheduled to precede others in performance, assesses the incidence and significance of marginal hypothyroidism in psychiatric inpatients. The effects of psychostimulants on patients with late consequences of closed head injury will also be studied. The Center's four basic science sections (one is new) are tied in various ways to each other and to the five clinical sections (two are new). Several studies focus on the HPT axis: with importance for peptide physiology generally, how is TRH synthesized; how do TRH and cholinergic systems interact in a model of depression (Porsolt test); does even slight hypothyroidism increase memory loss in rats after ECT? Some animal studies explore the utility of peptides as markers of adrenergic or cholinergic activity and the effects early separation on later HPT and HPA function. Other studies resonate with our developing interest in schizophrenia: changes in DA metabolism during the reproductive cycle; the effects of gonadal steroids on DAergic activity; the effects of diabetes on DA receptor functions. Six core groups (three are new) support the clinical and basic science sections and enhance each other's work. Teaching and training activities of the Center have increased in parallel with the depth and span of research activities.