EPIDEMIOLOGIC STUDIES OF DIET AND CANCER IN HAWAII

这是一份计划项目拨款或 饮食与癌症流行病学的主题。这一主题是通过 探索病因学假说和方法学的研究 饮食评估的各个方面。在当前的支持期内， 一项以人群为基础的4.2万名受试者的预期队列正在进行 癌症发病率与既往饮食的关系 摄入量；病例对照研究正在检验饮食假说 与肺癌、膀胱癌和甲状腺癌有关；以及 正在评估饮食记录方法回忆的准确性，因为 以及病例与对照之间召回的差异以及 代理受访者和直接受访对象之间的关系。 所有这些项目都取得了实质性进展， 给出了初步的研究结果。在续约期内，有六个 建议的项目包括：1)继续监测癌症 前瞻性队列中的发病率；2)病例对照研究(1057 1057例对照)膳食脂肪、纤维与膳食纤维的关系 钙摄入和能量平衡与结直肠癌的关系 3)一项病例对照研究(391例，782例对照) 膳食脂肪和维生素A与子宫内膜的可能联系 癌症风险；4)饮食因素与癌症的相关性研究 移居夏威夷的菲律宾人、高加索人和日本人的发病率； 5)饮食的病例对照研究(231例，462例对照) 维生素A、C、E和硒与皮肤病风险的关系 高加索人的恶性黑色素瘤；6)电话的发展 定量饮食史评估的访谈法。这个 病例对照研究将包括对受试者的直接访谈 他们的家，使用可视化的定量饮食历史方法 爱滋病。此外，对恶性黑色素瘤的研究将包括 测定视黄醇、胡萝卜素、α- 生育酚和硒。对未来队列的后续行动将 需要与夏威夷肿瘤登记处建立计算机化记录联系 和其他重要记录。电话采访研究将 包括与300人面对面和电话采访 研究对象。这些项目的数据收集、处理和分析 项目是高度整合的，并提供了协同效应和 节俭的努力，否则是不可能的。这个 这些研究的结果应该会加深我们对 饮食与癌症风险的关系和强化基础 为将来在初级预防中的公共卫生努力 癌症。

This is a renewal application for a Program Project Grant or the theme of diet and cancer epidemiology. This theme is pursued with studies that explore etiologic hypotheses as well as methodologic aspects of dietary assessment. In the current period of support, a population-based prospective cohort of 42,000 subjects is being followed for cancer incidence in relation to antecedent dietary intakes; case-control studies are testing dietary hypotheses related to lung, bladder and thyroid cancers; and the quantitative diet history method is being evaluated for accuracy of recall, as well as for differences in recall between cases versus controls and between proxy respondents versus directly-interviewed subjects. Substantial progress is being made on all of these projects and preliminary findings are presented. In the renewal period, six projects are proposed: 1) continued surveillance for cancer incidence in the prospective cohort; 2) a case-control study (1057 cases, 1057 controls) of the relationship of dietary fat, fiber and calcium intake, as well as energy balance, to colorectal cancer risk; 3) a case-control study (391 cases, 782 controls) of the possible association of dietary fat and vitamin A with endometrial cancer risk; 4) a correlational study of dietary factors and cancer incidence in Filipino, Caucasian and Japanese migrants to Hawaii; 5) a case-control study (231 cases, 462 controls) of dietary vitamins A, C and E and selenium in relation to risk of cutaneous malignant melanoma among Caucasians; 6) development of a telephone interview method for quantitative diet history assessment. The case-control studies will involve direct interviews of subjects in their homes, using a quantitative diet history method with visual aids. In addition, the study of malignant melanoma will include serum collections for assays of retinol, carotenes, alpha- tocopherol and selenium. Follow-up on the prospective cohort will entail computerized record-linkage with the Hawaii Tumor Registry and other vital records. The telephone interview study will include both face-to-face and telephone interviews with 300 subjects. Data collection, processing and analysis for these projects is highly integrated, and provides for synergism and economy in effort that would not otherwise be possible. The results of these studies should further our knowledge of the relationship of diet to cancer risk and strengthen the foundation for future public health efforts in the primary prevention of cancer.