Transcriptional control of macrophage function in the pig and its relationship to infectious disease susceptibility

猪巨噬细胞功能的转录控制及其与传染病易感性的关系

• 批准号: BB/G004013/1
• 负责人: David Hume
• 金额: $ 100.68万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FG004013%2F1
• 关键词: Transcriptional; control; macrophage; function; pig

This project is concerned with detailed studies of the immune system of the pig. The study takes a whole genome approach, and builds upon similar studies of the mouse and human by international consortia in which the Principal Investigator has participated. The focus is on the molecular biology of macrophages, large white blood cells that are the first line of defence against bacterial and some viral diseases. We aim to identify all of the genes that contribute to the host defence function in these cells in the pig, and how their expression is coordinated. Within that set of genes, we aim to identify those that vary in their function between pigs and other species, and between different major breeds of pigs. The outcome of the study will be to provide a rational basis for breeding pigs for improved disease resistance, identification of disease susceptibility genes that could also contribute to human health, and also a basic understanding of the evolution of immunity in mammals.

这个项目涉及对猪的免疫系统的详细研究。这项研究采用了全基因组方法，并建立在首席研究员参与的国际财团对老鼠和人类的类似研究的基础上。重点放在巨噬细胞的分子生物学上，巨噬细胞是抵御细菌和一些病毒疾病的第一道防线。我们的目标是在猪的这些细胞中识别所有有助于宿主防御功能的基因，以及它们的表达是如何协调的。在这组基因中，我们的目标是识别那些在猪和其他物种之间以及不同主要猪品种之间功能不同的基因。这项研究的结果将为培育提高抗病能力的猪提供合理的基础，识别也可能有助于人类健康的疾病易感基因，并对哺乳动物的免疫进化有一个基本的了解。

项目成果

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).

• DOI: 10.1016/j.cyto.2012.11.014
• 发表时间: 2013-02
• 期刊: CYTOKINE
• 影响因子: 3.8
• 作者: Gow, Deborah J.;Garceau, Valerie;Pridans, Clare;Gow, Adam G.;Simpson, Kerry E.;Gunn-Moore, Danielle;Hume, David A.
• 通讯作者: Hume, David A.

Structural and functional annotation of the porcine immunome.

猪免疫组的结构和功能注释。

• DOI: 10.1186/1471-2164-14-332
• 发表时间: 2013-05-15
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Dawson HD;Loveland JE;Pascal G;Gilbert JG;Uenishi H;Mann KM;Sang Y;Zhang J;Carvalho-Silva D;Hunt T;Hardy M;Hu Z;Zhao SH;Anselmo A;Shinkai H;Chen C;Badaoui B;Berman D;Amid C;Kay M;Lloyd D;Snow C;Morozumi T;Cheng RP;Bystrom M;Kapetanovic R;Schwartz JC;Kataria R;Astley M;Fritz E;Steward C;Thomas M;Wilming L;Toki D;Archibald AL;Bed'Hom B;Beraldi D;Huang TH;Ait-Ali T;Blecha F;Botti S;Freeman TC;Giuffra E;Hume DA;Lunney JK;Murtaugh MP;Reecy JM;Harrow JL;Rogel-Gaillard C;Tuggle CK
• 通讯作者: Tuggle CK

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide.

• DOI: 10.1186/1471-2164-14-581
• 发表时间: 2013-08-28
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Kapetanovic R;Fairbairn L;Downing A;Beraldi D;Sester DP;Freeman TC;Tuggle CK;Archibald AL;Hume DA
• 通讯作者: Hume DA

A gene expression atlas of the domestic pig.

• DOI: 10.1186/1741-7007-10-90
• 发表时间: 2012-11-15
• 期刊: BMC biology
• 影响因子: 5.4
• 作者: Freeman TC;Ivens A;Baillie JK;Beraldi D;Barnett MW;Dorward D;Downing A;Fairbairn L;Kapetanovic R;Raza S;Tomoiu A;Alberio R;Wu C;Su AI;Summers KM;Tuggle CK;Archibald AL;Hume DA
• 通讯作者: Hume DA

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

• DOI: 10.1371/journal.pgen.1006641
• 发表时间: 2017-03
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Baillie JK;Arner E;Daub C;De Hoon M;Itoh M;Kawaji H;Lassmann T;Carninci P;Forrest AR;Hayashizaki Y;FANTOM Consortium;Faulkner GJ;Wells CA;Rehli M;Pavli P;Summers KM;Hume DA
• 通讯作者: Hume DA