猪巨噬细胞功能的转录控制及其与传染病易感性的关系-猫眼课题宝

猪巨噬细胞功能的转录控制及其与传染病易感性的关系

批准号：

BB/G004013/1

负责人：

David Hume

金额：

$100.68万

依托单位：

University of Edinburgh

依托单位国家：

英国

项目类别：

Research Grant

财政年份：

2009

资助国家：

英国

项目状态：

已结题

起止时间：

2009 至 --

来源：

https://gtr.ukri.org/projects?ref=BB%2FG004013%2F1

关键词：

Transcriptional control macrophage function pig

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中文摘要

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英文摘要

This project is concerned with detailed studies of the immune system of the pig. The study takes a whole genome approach, and builds upon similar studies of the mouse and human by international consortia in which the Principal Investigator has participated. The focus is on the molecular biology of macrophages, large white blood cells that are the first line of defence against bacterial and some viral diseases. We aim to identify all of the genes that contribute to the host defence function in these cells in the pig, and how their expression is coordinated. Within that set of genes, we aim to identify those that vary in their function between pigs and other species, and between different major breeds of pigs. The outcome of the study will be to provide a rational basis for breeding pigs for improved disease resistance, identification of disease susceptibility genes that could also contribute to human health, and also a basic understanding of the evolution of immunity in mammals.

期刊论文(10)

专著(0)

科研奖励(0)

会议论文

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).

DOI： 10.1016/j.cyto.2012.11.014

发表时间： 2013-02

期刊：

CYTOKINE

影响因子： 3.8

作者：

[Gow, Deborah J., Garceau, Valerie, Pridans, Clare, Gow, Adam G., Simpson, Kerry E., Gunn-Moore, Danielle, Hume, David A.]

通讯作者： Hume, David A.

Structural and functional annotation of the porcine immunome.

猪免疫组的结构和功能注释。

DOI： 10.1186/1471-2164-14-332

发表时间： 2013-05-15

期刊：

BMC genomics

影响因子： 4.4

作者：

[Dawson HD, Loveland JE, Pascal G, Gilbert JG, Uenishi H, Mann KM, Sang Y, Zhang J, Carvalho-Silva D, Hunt T, Hardy M, Hu Z, Zhao SH, Anselmo A, Shinkai H, Chen C, Badaoui B, Berman D, Amid C, Kay M, Lloyd D, Snow C, Morozumi T, Cheng RP, Bystrom M, Kapetanovic R, Schwartz JC, Kataria R, Astley M, Fritz E, Steward C, Thomas M, Wilming L, Toki D, Archibald AL, Bed'Hom B, Beraldi D, Huang TH, Ait-Ali T, Blecha F, Botti S, Freeman TC, Giuffra E, Hume DA, Lunney JK, Murtaugh MP, Reecy JM, Harrow JL, Rogel-Gaillard C, Tuggle CK]

通讯作者： Tuggle CK

The impact of breed and tissue compartment on the response of pig macrophages to lipopolysaccharide.

DOI： 10.1186/1471-2164-14-581

发表时间： 2013-08-28

期刊：

BMC genomics

影响因子： 4.4

作者：

[Kapetanovic R, Fairbairn L, Downing A, Beraldi D, Sester DP, Freeman TC, Tuggle CK, Archibald AL, Hume DA]

通讯作者： Hume DA

A gene expression atlas of the domestic pig.

DOI： 10.1186/1741-7007-10-90

发表时间： 2012-11-15

期刊：

BMC biology

影响因子： 5.4

作者：

[Freeman TC, Ivens A, Baillie JK, Beraldi D, Barnett MW, Dorward D, Downing A, Fairbairn L, Kapetanovic R, Raza S, Tomoiu A, Alberio R, Wu C, Su AI, Summers KM, Tuggle CK, Archibald AL, Hume DA]

通讯作者： Hume DA

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.

DOI： 10.1371/journal.pgen.1006641

发表时间： 2017-03

期刊：

PLoS genetics

影响因子： 4.5

作者：

[Baillie JK, Arner E, Daub C, De Hoon M, Itoh M, Kawaji H, Lassmann T, Carninci P, Forrest AR, Hayashizaki Y, FANTOM Consortium, Faulkner GJ, Wells CA, Rehli M, Pavli P, Summers KM, Hume DA]

通讯作者： Hume DA