Functional Annotation of the Sheep Genome

绵羊基因组的功能注释

• 批准号: BB/L001209/1
• 负责人: David Hume
• 金额: $ 134.66万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL001209%2F1
• 关键词: Functional; Annotation; Sheep; Genome

Animals and humans are made up of many different kinds of organs and cells, each of which requires the actions of a subset of the genes in the genome. We currently know the function of only a subset of the genes in the genome. Much of what we know comes from studies of rodents but their biology is quite different to humans and their small size compromises their use. In the current study we will examine how individual genes are used in every tissue and cell of the sheep. From that information, we will be able to identify sets of genes that are always used together, and infer the function of genes of unknown function from the company they keep. That information will, in turn, allow us to interpret studies of the genetics and genomics of large animals, including humans (this study could not be done on a human). This will, in turn, inform the rational breeding of livestock for improved performance and welfare through selection for disease resistance. It will also give us a better understanding of the basic biology of humans that can be translated in better lifelong health.

动物和人类由许多不同种类的器官和细胞组成，每种器官和细胞都需要基因组中一部分基因的作用。目前我们只知道基因组中一部分基因的功能。我们所知道的大部分信息都来自对啮齿动物的研究，但它们的生物学特性与人类有很大不同，而且它们的小体型影响了它们的使用。在当前的研究中，我们将研究个体基因如何在羊的每个组织和细胞中使用。根据这些信息，我们将能够识别总是一起使用的基因组，并从它们所保留的基因中推断出功能未知的基因的功能。这些信息反过来将使我们能够解释包括人类在内的大型动物的遗传学和基因组学研究（这项研究无法在人类身上进行）。反过来，这将为牲畜的合理饲养提供信息，通过选择抗病性来提高性能和福利。它还将使我们更好地了解人类的基本生物学，这可以转化为更好的终生健康。

项目成果

Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression

反刍动物从出生到成年胃肠道的全面转录谱揭示了强烈的发育阶段特异性基因表达

• DOI: 10.1101/364752
• 发表时间: 2018
• 作者: Bush S

Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries.

• DOI: 10.1186/s12859-017-1714-9
• 发表时间: 2017-06-13
• 期刊: BMC bioinformatics
• 影响因子: 3
• 作者: Bush SJ;McCulloch MEB;Summers KM;Hume DA;Clark EL
• 通讯作者: Clark EL

Genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep

基因组分析支持奶羊产奶量和乳腺炎抵抗力同步遗传改良的可行性

• DOI: 10.1101/577015
• 发表时间: 2019
• 作者: Banos G

The genomic architecture of mastitis resistance in dairy sheep.

• DOI: 10.1186/s12864-017-3982-1
• 发表时间: 2017-08-16
• 期刊: BMC genomics
• 影响因子: 4.4
• 作者: Banos G;Bramis G;Bush SJ;Clark EL;McCulloch MEB;Smith J;Schulze G;Arsenos G;Hume DA;Psifidi A
• 通讯作者: Psifidi A

A high resolution atlas of gene expression in the domestic sheep (Ovis aries).

• DOI: 10.1371/journal.pgen.1006997
• 发表时间: 2017-09
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Clark EL;Bush SJ;McCulloch MEB;Farquhar IL;Young R;Lefevre L;Pridans C;Tsang HG;Wu C;Afrasiabi C;Watson M;Whitelaw CB;Freeman TC;Summers KM;Archibald AL;Hume DA
• 通讯作者: Hume DA