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Macrophage Biology and Disease Susceptibility in Poultry

家禽巨噬细胞生物学和疾病易感性

基本信息

批准号：
BB/M011925/1
负责人：
David Hume
金额：
$ 97.04万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FM011925%2F1
关键词：
Macrophage Biology Disease Susceptibility Poultry

项目摘要

Poultry are the largest source of animal protein world-wide. Sustainable production of meat and eggs requires the protection of the birds against a wide range of pathogens. Some of the current methods, including the use of antibiotics, are becoming less effective or have been banned because of hazards to human health. Our project combines two related approaches to overcoming some of the health issues of birds, by priming their immune systems either through the use of genetics or administration of natural proteins that normal control their immunity. Macrophages are large white blood cells that are first line of defence against pathogens, and also control the later acquired responses that are also induced by successful vaccines. Our project is based upon a number of proprietary discoveries about the way that macrophage biology is controlled in birds. On the one hand, we believe that there are many natural mutations in birds that compromise their immune systems and which have not been selected out in conventional breeding strategies. We aim to develop a simple assay that can detect the ability of macrophage to recognise and respond to a diverse set of infections, and show that the assay could be used to breed birds with improved disease resistance. On the other hand, we have identified a protein called CSF-1 which controls the numbers of macrophages in birds. We will test the ability of this protein to induce changes in growth and development of the immune system, and test the possibility that it could improve both innate disease resistance and the efficacy of existing and future vaccines.

家禽是世界上最大的动物蛋白来源。肉类和蛋类的可持续生产需要保护鸟类免受各种病原体的侵害。目前的一些方法，包括使用抗生素，由于对人类健康的危害而变得不那么有效或已被禁止。我们的项目结合了两种相关的方法来克服鸟类的一些健康问题，通过使用遗传学或管理正常控制其免疫力的天然蛋白质来启动它们的免疫系统。巨噬细胞是一种巨大的白色血细胞，是对抗病原体的第一道防线，也控制着成功疫苗诱导的后期获得性反应。我们的项目是基于一系列关于巨噬细胞生物学在鸟类中控制方式的专有发现。一方面，我们认为鸟类中有许多自然突变会损害它们的免疫系统，并且在传统的育种策略中没有被选择出来。我们的目标是开发一种简单的检测方法，可以检测巨噬细胞识别和应对各种感染的能力，并表明该方法可用于繁殖具有提高抗病能力的鸟类。另一方面，我们已经确定了一种名为CSF-1的蛋白质，它控制着鸟类巨噬细胞的数量。我们将测试这种蛋白质诱导免疫系统生长和发育变化的能力，并测试它是否可能提高先天性疾病抵抗力以及现有和未来疫苗的功效。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Functional annotation of the T-cell immunoglobulin mucin family in birds.

DOI：
10.1111/imm.12607
发表时间：
2016-07
期刊：
Immunology
影响因子：
6.4
作者：
Hu T;Wu Z;Vervelde L;Rothwell L;Hume DA;Kaiser P
通讯作者：
Kaiser P

Antigen Sampling CSF1R-Expressing Epithelial Cells Are the Functional Equivalents of Mammalian M Cells in the Avian Follicle-Associated Epithelium

DOI：
10.3389/fimmu.2019.02495
发表时间：
2019-10-22
期刊：
FRONTIERS IN IMMUNOLOGY
影响因子：
7.3
作者：
Balic, Adam;Chintoan-Uta, Cosmin;Vervelde, Lonneke
通讯作者：
Vervelde, Lonneke

Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.

鸡免疫系统中巨噬细胞集落刺激因子（CSF1）的调节和功能。

DOI：
10.1016/j.dci.2019.103586
发表时间：
2020
期刊：
Developmental and comparative immunology
影响因子：
2.9
作者：
Wu Z
通讯作者：
Wu Z

Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken.

DOI：
10.1186/s12864-018-4972-7
发表时间：
2018-08-07
期刊：
BMC genomics
影响因子：
4.4
作者：
Bush SJ;Freem L;MacCallum AJ;O'Dell J;Wu C;Afrasiabi C;Psifidi A;Stevens MP;Smith J;Summers KM;Hume DA
通讯作者：
Hume DA