Macrophage Biology and Disease Susceptibility in Poultry
家禽巨噬细胞生物学和疾病易感性
基本信息
- 批准号:BB/M011925/1
- 负责人:
- 金额:$ 97.04万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Poultry are the largest source of animal protein world-wide. Sustainable production of meat and eggs requires the protection of the birds against a wide range of pathogens. Some of the current methods, including the use of antibiotics, are becoming less effective or have been banned because of hazards to human health. Our project combines two related approaches to overcoming some of the health issues of birds, by priming their immune systems either through the use of genetics or administration of natural proteins that normal control their immunity. Macrophages are large white blood cells that are first line of defence against pathogens, and also control the later acquired responses that are also induced by successful vaccines. Our project is based upon a number of proprietary discoveries about the way that macrophage biology is controlled in birds. On the one hand, we believe that there are many natural mutations in birds that compromise their immune systems and which have not been selected out in conventional breeding strategies. We aim to develop a simple assay that can detect the ability of macrophage to recognise and respond to a diverse set of infections, and show that the assay could be used to breed birds with improved disease resistance. On the other hand, we have identified a protein called CSF-1 which controls the numbers of macrophages in birds. We will test the ability of this protein to induce changes in growth and development of the immune system, and test the possibility that it could improve both innate disease resistance and the efficacy of existing and future vaccines.
家禽是世界上最大的动物蛋白来源。肉类和蛋类的可持续生产需要保护鸟类免受多种病原体的侵害。目前的一些方法,包括使用抗生素,由于对人类健康的危害而变得不那么有效或已被禁止。我们的项目结合了两种相关的方法来克服鸟类的一些健康问题,通过使用遗传学或管理正常控制其免疫力的天然蛋白质来启动它们的免疫系统。巨噬细胞是大的白色血细胞,它们是抵抗病原体的第一道防线,并且还控制也由成功疫苗诱导的后来获得的应答。我们的项目是基于一系列关于巨噬细胞生物学在鸟类中控制方式的专有发现。一方面,我们认为鸟类中有许多自然突变会损害它们的免疫系统,并且在传统的育种策略中没有被选择出来。我们的目标是开发一种简单的检测方法,可以检测巨噬细胞识别和应对各种感染的能力,并表明该方法可用于繁殖具有提高抗病能力的鸟类。另一方面,我们已经确定了一种名为CSF-1的蛋白质,它控制着鸟类巨噬细胞的数量。我们将测试这种蛋白质诱导免疫系统生长和发育变化的能力,并测试它是否可能提高先天性疾病抵抗力以及现有和未来疫苗的功效。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Functional annotation of the T-cell immunoglobulin mucin family in birds.
- DOI:10.1111/imm.12607
- 发表时间:2016-07
- 期刊:
- 影响因子:6.4
- 作者:Hu T;Wu Z;Vervelde L;Rothwell L;Hume DA;Kaiser P
- 通讯作者:Kaiser P
Antigen Sampling CSF1R-Expressing Epithelial Cells Are the Functional Equivalents of Mammalian M Cells in the Avian Follicle-Associated Epithelium
- DOI:10.3389/fimmu.2019.02495
- 发表时间:2019-10-22
- 期刊:
- 影响因子:7.3
- 作者:Balic, Adam;Chintoan-Uta, Cosmin;Vervelde, Lonneke
- 通讯作者:Vervelde, Lonneke
Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.
鸡免疫系统中巨噬细胞集落刺激因子(CSF1)的调节和功能。
- DOI:10.1016/j.dci.2019.103586
- 发表时间:2020
- 期刊:
- 影响因子:2.9
- 作者:Wu Z
- 通讯作者:Wu Z
Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken.
- DOI:10.1186/s12864-018-4972-7
- 发表时间:2018-08-07
- 期刊:
- 影响因子:4.4
- 作者:Bush SJ;Freem L;MacCallum AJ;O'Dell J;Wu C;Afrasiabi C;Psifidi A;Stevens MP;Smith J;Summers KM;Hume DA
- 通讯作者:Hume DA
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David Hume其他文献
A continuum of expanders
- DOI:
10.4064/fm101-11-2016 - 发表时间:
2014-10 - 期刊:
- 影响因子:0
- 作者:
David Hume - 通讯作者:
David Hume
Expresión específica de genes de la respuesta inflamactoria en subpoblaciones de macrófagos
炎症反应基因特异表达
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
V. Ripoll;David Hume;M. Fontanilla - 通讯作者:
M. Fontanilla
A Treatise of Human Nature: Being an Attempt to introduce the experimental Method of Reasoning into Moral Subjects
- DOI:
10.2307/2216614 - 发表时间:
1972-04 - 期刊:
- 影响因子:0
- 作者:
David Hume - 通讯作者:
David Hume
Direct embeddings of relatively hyperbolic groups with optimal $\ell^p$ compression exponent
- DOI:
10.1515/crelle-2013-0040 - 发表时间:
2011-11 - 期刊:
- 影响因子:0
- 作者:
David Hume - 通讯作者:
David Hume
David Hume: Enquiries Concerning Human Understanding and Concerning the Principles of Morals (Third Edition)
大卫·休谟:关于人类理解和道德原则的探究(第三版)
- DOI:
- 发表时间:
1975 - 期刊:
- 影响因子:0
- 作者:
David Hume;P. Nidditch - 通讯作者:
P. Nidditch
David Hume的其他文献
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{{ truncateString('David Hume', 18)}}的其他基金
Coarse Geometry of Groups and Spaces
群和空间的粗略几何
- 批准号:
EP/V027360/2 - 财政年份:2023
- 资助金额:
$ 97.04万 - 项目类别:
Fellowship
Coarse Geometry of Groups and Spaces
群和空间的粗略几何
- 批准号:
EP/V027360/1 - 财政年份:2021
- 资助金额:
$ 97.04万 - 项目类别:
Fellowship
CSF1R in homeostasis and immunity
CSF1R 在体内平衡和免疫中的作用
- 批准号:
MR/M019969/1 - 财政年份:2015
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
Understanding resistance and differential vaccine responses to Eimeria in the chicken - novel biomarkers and genetic control.
了解鸡对艾美耳球虫的耐药性和差异疫苗反应 - 新型生物标志物和遗传控制。
- 批准号:
BB/L004003/1 - 财政年份:2014
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
Transcriptome analysis in Indian buffalo and the genetics of innate immunity
印度水牛的转录组分析和先天免疫的遗传学
- 批准号:
BB/L004623/1 - 财政年份:2014
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
Functional Annotation of the Sheep Genome
绵羊基因组的功能注释
- 批准号:
BB/L001209/1 - 财政年份:2013
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
Development of applications of CSF-1 and IL34 in livestock
CSF-1和IL34在家畜中的应用进展
- 批准号:
BB/I013113/1 - 财政年份:2012
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
CSF1 and the control of postnatal growth and organ development in the rat
CSF1 与大鼠出生后生长和器官发育的控制
- 批准号:
G0901193/1 - 财政年份:2010
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
CSF1 IL34 and the function of Macrophages in Avian Development
CSF1 IL34 和巨噬细胞在禽类发育中的功能
- 批准号:
BB/H012559/1 - 财政年份:2010
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
Transcriptional control of macrophage function in the pig and its relationship to infectious disease susceptibility
猪巨噬细胞功能的转录控制及其与传染病易感性的关系
- 批准号:
BB/G004013/1 - 财政年份:2009
- 资助金额:
$ 97.04万 - 项目类别:
Research Grant
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