CANNABIS AND CIGARETTE EXPOSURE-LONG TERM EFFECTS

吸食大麻和香烟的长期影响

• 批准号: 3210672
• 负责人: PETER A FRIED
• 金额: $ 10.08万
• 依托单位: CARLETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210672
• 关键词: attention; auditory discrimination; behavior prediction; behavior test; child mental disorders; embryo /fetus drug adverse effect; female; intelligence; language development; learning disorders; longitudinal human study; marijuana abuse; memory; mental disorder diagnosis; middle childhood (6-11); neuropsychological tests; passive smoking; postnatal growth disorder; problem solving; psychomotor function; sensory discrimination; tobacco abuse; touch; verbal behavior; visual perception

Since 1978, a longitudinal study investigating the effects of marihuana and cigarettes used during pregnancy has been underway. The overall purpose of this Ottawa Prenatal Prospective Study is to examine the effects of these drugs on pregnancy, the neonate and the young child. The general objective of this competitive renewal is to determine whether particular developmental delays and behavioral difficulties observed in the newborn, infant, and young child that are' statistically associated, in a differential fashion, with prenatal marihuana and cigarette exposure persist in the 6 & 7 year old child and whether, by an in depth neurobehavioural assessment, a greater degree of specificity of dysfunction can be identified., Additionally, because of the longitudinal nature of the work, the predictive validity of the infant tests can be examined as can the continuity of effects over age. The neurobehavioural battery will include an assessment of fine and gross motor abilities, sensory skills (tactile, visual & auditory), kinesthetic functioning, visual-spatial capabilities, language skills, reasoning ability, memory (visual, tactile and language), intelligence, academic readiness, phonemic awareness and overall behavior. Maternal variables (e.g. health, nutrition, parity, age, other drugs, intelligence) and postnatal, environmental variables ( e.g. home environment, second-hand smoke, preschool experience) will be included in multivariate statistical analyses. The Ottawa study is the only work to have published data on marihuana offspring beyond a year of age and is the most comprehensive longitudinal work examining 6-7 year old children of cigarettes smokers. The testing of children of this age is particularly critical as the identification of subtle learning difficulties is most likely to come from studies of this age group.

自1978年以来，一项纵向研究调查了 禁止在怀孕期间使用大麻和香烟。 的 这项渥太华产前前瞻性研究的总体目的是检查 这些药物对妊娠、新生儿和幼儿的影响。 的 本次竞争性续约的总体目标是确定 特别是发育迟缓和行为困难， 新生儿、婴儿和幼儿在统计学上是相关的， 不同的方式，产前大麻和香烟暴露 坚持在6&7岁的孩子，是否，由一个在深度 神经行为评估，功能障碍的特异性程度更高 可以识别。此外，由于纵向的性质， 工作，婴儿测试的预测有效性可以检查，因为可以 影响随年龄的延续性。 神经行为电池将包括对罚款和 大运动能力，感觉技能（触觉，视觉和听觉）， 动觉功能，视觉空间能力，语言能力， 推理能力，记忆力（视觉，触觉和语言），智力， 学业准备，音素意识和整体行为。 产妇 变量（如健康、营养、产次、年龄、其他药物、智力） 和产后，环境变量（如家庭环境，二手 吸烟、学龄前经历）将被纳入多变量统计 分析。 渥太华的这项研究是唯一一项公布了大麻数据的研究 一岁以上的后代，是最全面的纵向 检查6-7岁吸烟儿童的工作。 测试 这一年龄段的儿童尤其重要，因为 微妙的学习困难最有可能来自于对这一点的研究。 年龄段