PRENATAL CANNABIS AND CIGARETTES--ADOLESCENT OUTCOMES

描述：(申请人摘要) 自1978年以来，一项纵向调查一直在进行中，在低 危险人群、吸食大麻和吸烟的影响 怀孕了。这项渥太华产前前瞻性研究的总体目的 (OPPS)是为了检查这些药物对怀孕、新生儿的影响 以及学龄前和学龄儿童。这样做的总体目标是 竞争更新是为了确定发展后遗症和 OPS受试者中观察到的行为困难，统计 与产前大麻和香烟有区别地联系在一起 暴露，在青少年(13-15岁)中持续存在，以及是否在 深度神经行为评估，特异度更高 功能障碍是可以识别的。因为这是纵向的 OPS，婴儿和儿童早期测试的预测有效性可以 还可以考察影响随年龄变化的连续性。 神经行为单元将专注于我们拥有的那些行为 被确定为对有问题的药物敏感，并强调 在当前供资期间已注意到的行为方面 检查9个1/2-12岁的儿童，即子宫内大麻与 行政职能和协会的曝光率和具体方面 宫内吸烟暴露与语音表现受损之间的关系 语言/阅读、认知和知觉加工的形式 涉及到对细节的关注。评估将包括一次考试 记忆、注意力、战略规划、语言和阅读的各个方面， 复杂问题的解决和涉及到的微分过程 对刺激的结构方面和细节方面的感知分析。一个 还将对基本内容中的能力进行区分 领域与能力在这种材料的在线集成中的对比 在能够执行执行功能任务之前是必需的。 行为、性发育以及吸烟和吸烟的评估 接触二手烟(使用尿液分析和问卷调查)将 也在青少年中进行评估。母亲变量(例如，健康， 营养、胎次、教育、年龄、其他药物、智力、个性) 而出生后，环境变量将包含在多变量中 统计分析。 OPS是唯一一部公布大麻使用者数据的作品 超越童年早期的后代，是最全面的纵向 检查吸烟者的学龄儿童的工作。测试的测试 儿童在青春期中期的身份认同尤为关键 细微的学习困难最有可能在以下情况下显现出来 通常情况下，复杂的行为需要集中注意力和认知技能 目前发展到这个阶段，可以深入考察。

DESCRIPTION: (Applicant's Abstract) Since 1978, a longitudinal study has been underway investigating, in a low risk population, the effects of marijuana and cigarettes used during pregnancy. The overall purpose of this Ottawa Prenatal Prospective Study (OPPS) is to examine the effects of these drugs on pregnancy, the neonate and the pre-school and school aged offspring. The general objective of this competitive renewal is to determine whether developmental sequelae and behavioral difficulties observed in the OPPS subjects, statistically associated in a differential fashion with prenatal marijuana and cigarette exposure, persist in the adolescent (13-15 year old) and whether, by an in depth neurobehavioral assessment, a greater degree of specificity of dysfunction can be identified. Because of the longitudinal nature of this OPPS, the predictive validity of the infant and early childhood tests can also be examined as can the continuity of effects over age. The neurobehavioral battery will focus upon those behaviors which we have identified to be vulnerable to the drugs in question with an emphasis upon facets of behavior that have been noted in the currently funded period examining 9 1/2 -12 year olds i.e. an association between in utero marijuana exposure and specific aspects of executive function and an association between in utero cigarette exposure and impaired performance in phonological aspects of language/reading, cognition and forms of perceptual processing involving attention to detail. The assessment will include an examination of memory, attention, strategic planning, aspects of language and reading, complex problem solving and the differential processes involved in the perceptual analysis of configural versus detailed aspects of stimuli. A distinction will also be made between the capabilities in basic content domains versus competency in the on-line integration of such material that is required prior to being able to perform executive function tasks. Behavior, sexual development and an assessment of both cigarette smoking and exposure to second hand smoke (using urine analysis and questionnaires) will also be evaluated in the adolescents. Maternal variables (e.g. health, nutrition, parity, education, age, other drugs, intelligence, personality) and postnatal, environmental variables will be included in multivariate statistical analysis. The OPPS is the only work to have published data on marijuana users' offspring beyond early childhood and is the most comprehensive longitudinal work examining school age children of cigarette smokers. The testing of children at mid-adolescence is particularly critical as the identification of subtle learning difficulties is most likely to manifest themselves when complex behaviors requiring focused attention and cognitive skills, normally present at this stage of development, can be examined in depth.