CANNABIS AND CIGARETTE EXPOSURE-LONG TERM EFFECTS

自1978年以来，一项纵向研究调查了 怀孕期间使用的大麻和香烟一直在进行中。这个 这项渥太华产前前瞻性研究的总体目的是检查 这些药物对怀孕、新生儿和幼儿的影响。这个 这次竞争性更新的总体目标是确定 观察到的特殊发育迟缓和行为困难 新生儿、婴儿和幼儿在统计上是相关的， 不同的时尚，产前吸食大麻和吸烟 坚持在6岁和7岁的孩子和是否，由一个深入 神经行为评估，功能障碍的特异度更高 可以被识别。此外，由于 工作中，可以尽可能地检查婴儿测试的预测有效性 随着年龄的增长影响的延续性。 神经行为单元将包括对罚款和 粗大的运动能力、感觉技能(触觉、视觉和听觉)， 动觉功能，视觉空间能力，语言技能， 推理能力、记忆力(视觉、触觉和语言)、智力、 学习准备、音素意识和整体行为。母性 变量(如健康、营养、产次、年龄、其他药物、智力) 和出生后的环境变量(例如家庭环境、二手环境 吸烟、学龄前经历)将包括在多变量统计中 分析。 渥太华的研究是唯一公布大麻数据的工作 超过一岁的后代，是最全面的纵向 检查吸烟者的6-7岁儿童的工作。测试 对于这个年龄段的儿童来说尤其关键，因为识别 微妙的学习困难最有可能来自对此的研究 年龄段。

Since 1978, a longitudinal study investigating the effects of marihuana and cigarettes used during pregnancy has been underway. The overall purpose of this Ottawa Prenatal Prospective Study is to examine the effects of these drugs on pregnancy, the neonate and the young child. The general objective of this competitive renewal is to determine whether particular developmental delays and behavioral difficulties observed in the newborn, infant, and young child that are' statistically associated, in a differential fashion, with prenatal marihuana and cigarette exposure persist in the 6 & 7 year old child and whether, by an in depth neurobehavioural assessment, a greater degree of specificity of dysfunction can be identified., Additionally, because of the longitudinal nature of the work, the predictive validity of the infant tests can be examined as can the continuity of effects over age. The neurobehavioural battery will include an assessment of fine and gross motor abilities, sensory skills (tactile, visual & auditory), kinesthetic functioning, visual-spatial capabilities, language skills, reasoning ability, memory (visual, tactile and language), intelligence, academic readiness, phonemic awareness and overall behavior. Maternal variables (e.g. health, nutrition, parity, age, other drugs, intelligence) and postnatal, environmental variables ( e.g. home environment, second-hand smoke, preschool experience) will be included in multivariate statistical analyses. The Ottawa study is the only work to have published data on marihuana offspring beyond a year of age and is the most comprehensive longitudinal work examining 6-7 year old children of cigarettes smokers. The testing of children of this age is particularly critical as the identification of subtle learning difficulties is most likely to come from studies of this age group.