KINETICS OF FETAL LEUCINE AND KETOISOCAPROATE METABOLISM

胎儿亮氨酸和酮异己酸代谢动力学

基本信息

  • 批准号:
    3319916
  • 负责人:
  • 金额:
    $ 13.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1986
  • 资助国家:
    美国
  • 起止时间:
    1986-12-01 至 1989-11-30
  • 项目状态:
    已结题

项目摘要

Normal fetal growth is critical to postnatal growth and development. Fetal metabolism and, in particular, energy requirements and fetal protein metabolism are directly associated with intrauterine growth. The overall objective of this proposal is to enhance our understanding of protein metabolism in the fetus during intrauterine life by assessing quantitatively the kinetics of amino acid metabolism and by characterizing the effect of metabolic changes in the mother on these indices of fetal metabolism. The endogenous flux rates of leucine as a representative essential amino acid as well as the flux rates of its ketoacid ketoisocaproic acid (KIC) and the rates of leucine carbon oxidation will be determined using a double isotope dilution technique in the chronically catheterized ovine fetus model. These dynamic quantitative aspects of amino acid metabolism will be used as kinetic indices of endogenous fetal protein metabolism in order to explore the effect of: A. Maternal fasting since fasting and undernutrition in the mother are associated with fetal growth retardation. B. Leucine infusion to the mother since leucine has been shown to play a regulatory role on protein metabolism in vitro and in vivo and therefore its effect on maternal protein metabolism may influence fetal amino acid metabolism and subsequently intrauterine growth. C. Fetal hyperinsulinemia during euglycemia as it occurs during poor control of maternal diabetes mellitus, which is associated with fetal overgrowth and metabolic changes in the fetus that are responsible for increased morbidity and mortality during intrauterine and immediate postnatal life. D. Maternal hypoglycemia as it occurs during strict control of diabetes mellitus in the mother. This study will enhance our understanding of fetal protein metabolism and the factors affecting this metabolism and possibly provide us with methods of therapeutic intervention during and following intrauterine life.
正常的胎儿生长对出生后的生长发育至关重要。胎儿

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

EVA TSALIKIAN其他文献

EVA TSALIKIAN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('EVA TSALIKIAN', 18)}}的其他基金

NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES
1 型糖尿病发展的自然史研究
  • 批准号:
    7604849
  • 财政年份:
    2007
  • 资助金额:
    $ 13.34万
  • 项目类别:
REAL-TIME CONTINUOUS GLUCOSE MONITORING IN THE MANAGEMENT OF TYPE 1 DIABETES
实时连续血糖监测在 1 型糖尿病治疗中的应用
  • 批准号:
    7604925
  • 财政年份:
    2007
  • 资助金额:
    $ 13.34万
  • 项目类别:
NAVIGATOR CONTINUOUS GLUCOSE SENSOR TO MANAGE PEDIATRIC TYPE 1 DIABETES
用于管理儿童 1 型糖尿病的 NAVIGATOR 连续血糖传感器
  • 批准号:
    7604846
  • 财政年份:
    2007
  • 资助金额:
    $ 13.34万
  • 项目类别:
ACCURACY OF CONTINUOUS GLUCOSE MONITORS IN CHILDREN WITH T1DM
T1DM 儿童连续血糖监测仪的准确性
  • 批准号:
    7604928
  • 财政年份:
    2007
  • 资助金额:
    $ 13.34万
  • 项目类别:
NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES
1 型糖尿病发展的自然史研究
  • 批准号:
    7377063
  • 财政年份:
    2006
  • 资助金额:
    $ 13.34万
  • 项目类别:
BASAL INSULIN DURING EXERCISE ON THE DEVELOPMENT OF HYPOGLYCEMIA
运动期间基础胰岛素对低血糖发生的影响
  • 批准号:
    7377074
  • 财政年份:
    2006
  • 资助金额:
    $ 13.34万
  • 项目类别:
NAVIGATOR CONTINUOUS GLUCOSE SENSOR TO MANAGE PEDIATRIC TYPE 1 DIABETES
用于管理儿童 1 型糖尿病的 NAVIGATOR 连续血糖传感器
  • 批准号:
    7377060
  • 财政年份:
    2006
  • 资助金额:
    $ 13.34万
  • 项目类别:
GLUCOWATCH BIOGRAPHER IN THE MANAGEMENT OF TYPE 1 DIABETES IN CHILDREN
GLUCOWATCH 传记家治疗儿童 1 型糖尿病
  • 批准号:
    7201325
  • 财政年份:
    2005
  • 资助金额:
    $ 13.34万
  • 项目类别:
EXERCISE ON HYPOGLYCEMIA IN CHILDREN WITH TYPE 1 DIABETES
针对 1 型糖尿病儿童低血糖的运动
  • 批准号:
    7201374
  • 财政年份:
    2005
  • 资助金额:
    $ 13.34万
  • 项目类别:
GlucoWatch Biographer in the Management of Type 1 DM
GlucoWatch 传记作者治疗 1 型糖尿病
  • 批准号:
    7040805
  • 财政年份:
    2004
  • 资助金额:
    $ 13.34万
  • 项目类别:

相似国自然基金

一碳代谢(One carbon metabolism)介导上调的 PD1/PDL1 驱动 肿瘤免疫逃逸
  • 批准号:
    2024JJ9491
  • 批准年份:
    2024
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
三维碳纳米材料(nano-carbon@ZSM-5)的制备及应用
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    30 万元
  • 项目类别:
    青年科学基金项目
理论预言的三维碳同素异构体T-carbon的制备及其物性的实验深入研究
  • 批准号:
  • 批准年份:
    2020
  • 资助金额:
    58 万元
  • 项目类别:
    面上项目
绿色热量运动驱动的G-Carbon系统碳生产力发展研究
  • 批准号:
    51976085
  • 批准年份:
    2019
  • 资助金额:
    56.0 万元
  • 项目类别:
    面上项目
金属有机框架ZIF-67基Co@Carbon膜催化反应器设计、制备及其用于丙烷催化脱氢反应过程强化研究
  • 批准号:
    21878100
  • 批准年份:
    2018
  • 资助金额:
    66.0 万元
  • 项目类别:
    面上项目
多级g-C3N4/Carbon复合物的合成及可见光光催化研究
  • 批准号:
    51402147
  • 批准年份:
    2014
  • 资助金额:
    25.0 万元
  • 项目类别:
    青年科学基金项目
黄、东海沉积物中碳黑(Black Carbon)的地球化学研究
  • 批准号:
    40576039
  • 批准年份:
    2005
  • 资助金额:
    40.0 万元
  • 项目类别:
    面上项目

相似海外基金

Understanding and Improving Electrochemical Carbon Dioxide Capture
了解和改进电化学二氧化碳捕获
  • 批准号:
    MR/Y034244/1
  • 财政年份:
    2025
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Fellowship
Bio-MATSUPER: Development of high-performance supercapacitors based on bio-based carbon materials
Bio-MATSUPER:开发基于生物基碳材料的高性能超级电容器
  • 批准号:
    EP/Z001013/1
  • 财政年份:
    2025
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Fellowship
Collaborative Research: Non-Linearity and Feedbacks in the Atmospheric Circulation Response to Increased Carbon Dioxide (CO2)
合作研究:大气环流对二氧化碳 (CO2) 增加的响应的非线性和反馈
  • 批准号:
    2335762
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Modulating H2O Activity Promotes CO2 Reduction to Multi-Carbon Products
调节 H2O 活性可促进多碳产品的 CO2 还原
  • 批准号:
    2326720
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
CAS: Reductive Functionalization of Carbon Dioxide with Light Olefins
CAS:二氧化碳与轻质烯烃的还原官能化
  • 批准号:
    2349537
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Conference: Workshop on Mobilizing Our Universities for Education on Energy Use, Carbon Emissions, and Climate Change
会议:动员大学开展能源使用、碳排放和气候变化教育研讨会
  • 批准号:
    2402605
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Collaborative Research: Understanding Environmental and Ecological Controls on Carbon Export and Flux Attenuation near Bermuda
合作研究:了解百慕大附近碳输出和通量衰减的环境和生态控制
  • 批准号:
    2318940
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Collaborative Research: Non-Linearity and Feedbacks in the Atmospheric Circulation Response to Increased Carbon Dioxide (CO2)
合作研究:大气环流对二氧化碳 (CO2) 增加的响应的非线性和反馈
  • 批准号:
    2335761
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Collaborative Research: EAGER: Energy for persistent sensing of carbon dioxide under near shore waves.
合作研究:EAGER:近岸波浪下持续感知二氧化碳的能量。
  • 批准号:
    2339062
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Standard Grant
Mineral Biosequestration of Organic Carbon in Early Pedogenesis of Tailings
尾矿成土早期有机碳的矿物生物封存
  • 批准号:
    DP240102434
  • 财政年份:
    2024
  • 资助金额:
    $ 13.34万
  • 项目类别:
    Discovery Projects
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了