AUDITORY EVOKED BRAIN POTENTIALS IN NEUROLOGICAL DISEASE

神经系统疾病中听觉诱发的大脑电位

• 批准号: 3564454
• 负责人: Arnold Starr
• 金额: $ 46.95万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3564454
• 关键词: Cercopithecidae; aphasia; auditory cortex; auditory discrimination; auditory feedback; auditory pathways; auditory stimulus; axon; binaural hearing; cats; cognition disorders; guinea pigs; hearing tests; neural information processing; neuropsychological tests; psychoacoustics; semantics; short term memory; sonar; stimulus /response

We plan to study auditory evoked potentials (AEPs) in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials and their application to disordered brain function. In particular, we will study in experimental animals the role of cells and nerve fibers in generating far-field auditory brainstem components using specific lesion methods and in an in-vitro model system using nerve fibers passing between fluid compartments of different volumes and impedances. Long-latency AEPs related to the encoding of words and tones and their subsequent memorization will be studied in normal subjects and patients with focal hemispheric lesions to define neural correlates of language processing and auditory memory. The definition of binaural processes relevant for sound localization will be defined in middle and long-latency AEPs by the occurence of binaural interaction components and related to several psychoacoustic measures in normal subjects, patients with neurological lesions, and in children during maturation.

我们计划研究这两个脑区的听觉诱发电位。 临床神经功能障碍和动物实验来定义 这些电位产生的神经机制和 它们在治疗大脑功能紊乱方面的应用。特别是，我们 将在实验动物中研究细胞和神经的作用 产生远场听觉脑干成分的纤维 使用特定的损伤方法并在体外模型系统中 利用神经纤维在脑室的液体间穿行 不同的音量和阻抗。与长延迟AEP相关的 涉及单词和声调的编码以及它们随后的 记忆研究将在正常受试者和患者身上进行。 通过局灶性半球病变来定义神经相关性 语言处理和听觉记忆。概念的定义 将定义与声音定位相关的双耳过程 双耳诱发的中、长潜伏期AEP 相互作用的组成部分和相关的几个心理声学 在正常受试者、神经损伤患者中进行测量， 在成熟的儿童中也是如此。