FACTORS DETERMINING MAXIMAL EXERCISE PERFORMANCE IN MAN

决定人类最大运动表现的因素

• 批准号: 3817603
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817603
• 关键词: aging; body composition; body physical activity; body weight; cardiac output; cardiovascular stress test; clinical chemistry; exercise; gender difference; heart disorder diagnosis; heart imaging /visualization /scanning; human middle age (35-64); human old age (65+); intracardiac volume; mathematical model; model design /development; myocardial ischemia /hypoxia; oxygen consumption; peripheral blood vessel; radionuclide diagnosis; radiotracer

We have recently demonstrated in 184 non endurance trained non obese men and women from the BLSA with normal maximal exercise ECG's that the age-associated decline in VO2 max was markedly attenuated after VO2 max was normalized for total muscle mass instead of body weight. These results suggested an important role of peripheral (vs central circulatory) factors in the age-related reduction of maximal aerobic performance. A closely related issue is whether the well documented marked increase in maximal oxygen-consumption (VO2 max) of older endurance trained men relative to that of age-matched peers is mediated primarily by central versus peripheral adaptations. We performed radionuclide ventriculography and VO2 measurements during maximal upright bicycle ergometry in 8 endurance trained (mean age = 65 plus/minus 5 yr, treadmill VO2 max = 51 plus/minus 4 ml/kg, min) men.

我们最近在184个非耐力训练的非