EFFICACY OF DIGITALIS IN CONGESTIVE HEART FAILURE AND IN NORMAL SUBJECTS

我们先前在一项双盲交叉研究中表明，洋地黄 可停药3个月，无不良临床影响， 在30例稳定的受试者中，贲门大小和功能仅发生轻微变化， 充血性心力衰竭（CHF）和窦性心律。 的长期随访 这些患者证实了洋地黄的这种有利的早期反应， 戒断 我们已经开始了一项新的研究， 洋地黄对运动中有氧能力和心功能的影响 （通过门控血池扫描测量）及其对心律的影响， 慢性CHF和窦性心律患者的新组。 我们的小组与专家一起帮助制定了一份调查问卷 在不同大学的心脏病学。 这份调查表已 在美国心脏协会的帮助下， 学术界和执业医师的代表性群体， 目前的使用和对有效性和毒性的理解 洋地黄苷 研究结果对于确定 共识和存在重大不确定性的领域;重要的 后者中的类别将作为未来研究的基础 NIH和NIA可能会直接参与的项目。

We have previously shown in a double-blind crossover study that digitalis could be discontinued for three months without adverse clinical effect and only minor changes in caridac size and function in 30 subjects with stable congestive heart failure (CHF) and sinus rhythm. Long-term follow-up of these atients verified this favorable early response to digitalis withdrawal. We have initiated a new study to investigate the effects of digitalis on aerobic performance and cardiac function during exercise (measured via gated blood pool scan) and its effects on cardiac rhythm in a new group of patients with chronic CHF and sinus rhythm. Our group has helped to develop a questionnaire in conjunction with experts in cardiology at difference universities. This questionnaire has been implemented with the help of the American Heart Association to sample representative groups of academic and practicing physicians in their current use and understanding of the effectiveness and toxicity of digitalis glycosides. The results will be important in identifying areas of consensus and areas in which major uncertainties exist; the important categories within the latter will serve as a basis for future research projects in which NIH and NIA may find a direct role.