AMBULATORY ELECTROCARDIOGRAPHY AND BLOOD PRESSURE MEASUREMENT IN NORMAL MAN

正常人的动态心电图和血压测量

• 批准号: 3823129
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823129
• 关键词: aging; blood pressure; cerebrovascular disorders; circadian rhythms; congestive heart failure; electrocardiography; heart function; human middle age (35-64); human old age (65+); human subject; hypertension; outpatient care; patient monitoring device; sleep; young adult human (21-34)

Initial ambulatory electrocardiographic data from this laboratory has characterized the normal heart rhythm patterns in healthy elderly subjects. We have extended these efforts to include younger men and women (ages 25-60). In addition, we have added a new dimension - 24 hour ambulatory blood pressure (BP) recording - simultaneous with the ambulatory ECG recording, in normal subjects as well as hypertensives and those with congestive heart failure. We have analyzed the circadian variability of blood pressure, recorded every 7.5 min, over 24 hours in 26 healthy normotensive BLSA women ages 35-75 years using this technique. Both the mean waking systolic blood pressure (SBP) and its standard deviation increased with age wheras during sleep, the mean SBP but not its standard deviation increased with age. The difference between maximum and minimum hourly-averaged waking SBP increased with age whereas the difference during sleep was not age-related. Thus, in ambulatory, normotensive women, the variability of SBP increased with age during waking hours but not during sleep.

该实验室的初始动态心电图数据 描述了健康老年人的正常心律模式 科目 我们已将这些努力扩大到包括年轻男女 (ages第25至60段）。 此外，我们还增加了一个新的维度- 24小时 动态血压（BP）记录-与动态 ECG记录，在正常受试者以及高血压患者和 充血性心力衰竭 我们分析了血压的昼夜变化，记录了 在26名健康血压正常的BLSA女性中，每7.5分钟，超过24小时 35-75岁使用这种技术。 清醒时的平均收缩压 收缩压（SBP）及其标准差随年龄增长而增加， 睡眠，平均SBP，但不是其标准差随年龄的增加。 的 最大和最小小时平均清醒SBP之间的差异增加 而睡眠时的差异与年龄无关。 因此在 对于血压正常的非卧床女性，SBP的变异性随年龄增加而增加 在清醒的时候，而不是在睡眠的时候。

项目成果

Computer Vision Applied to Detect Lethargy through Animal Motion Monitoring: A Trial on African Swine Fever in Wild Boar.

• DOI: 10.3390/ani10122241
• 发表时间: 2020-11-29
• 期刊: Animals : an open access journal from MDPI
• 作者: Fernández-Carrión E;Barasona JÁ;Sánchez Á;Jurado C;Cadenas-Fernández E;Sánchez-Vizcaíno JM
• 通讯作者: Sánchez-Vizcaíno JM

High-Fat-Diet-Evoked Disruption of the Rat Dorsomedial Hypothalamic Clock Can Be Prevented by Restricted Nighttime Feeding.

• DOI: 10.3390/nu14235034
• 发表时间: 2022-11-26
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Sanetra AM;Palus-Chramiec K;Chrobok L;Jeczmien-Lazur JS;Gawron E;Klich JD;Pradel K;Lewandowski MH
• 通讯作者: Lewandowski MH