Statistical physics of cognition

认知统计物理学

• 批准号: EP/W024020/1
• 负责人: Simon Schultz
• 金额: $ 275.96万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW024020%2F1
• 关键词: Statistical; physics; cognition

This project asks how the statistical mechanics of critical processes such as avalanches underpin mammalian cognition. This is important because self-organising criticality has been proposed as a general explanation of the architecture and operating point of brain circuitry, however until now it has not been possible to relate it to cognitive function itself. We bring an inter-disciplinary approach to bear upon this problem, simulating neuronal mechanisms at scales from sub-cellular to brain-wide, and employing a new mesoscopic neuroimaging technology to detect avalanches and measure distance to criticality in very large (~10,000) populations of neurons during a cognitive task. This will bring new insight into system-wide brain function during health and disease states.

该项目探讨雪崩等关键过程的统计力学如何支撑哺乳动物的认知。这很重要，因为自组织临界性已被提出作为大脑电路的架构和操作点的一般解释，但到目前为止，还不可能将其与认知功能本身联系起来。我们采用跨学科方法来解决这个问题，模拟从亚细胞到全脑范围内的神经元机制，并采用新的介观神经成像技术来检测认知任务期间大量（约 10,000 个）神经元群体的雪崩并测量临界距离。这将为健康和疾病状态下全系统大脑功能带来新的见解。

项目成果

Neuronal signature of spatial decision-making during navigation by freely moving rats by using calcium imaging.

• DOI: 10.1073/pnas.2212152119
• 发表时间: 2022-11
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Two-Photon Targeted, Quad Whole-Cell Patch-Clamping Robot

双光子靶向四全细胞膜片钳机器人

• DOI: 10.1101/2022.11.14.516499
• 发表时间: 2022
• 作者: Vera Gonzalez G

Long- and short-term history effects in a spiking network model of statistical learning.

• DOI: 10.1038/s41598-023-39108-3
• 发表时间: 2023-08-09
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Maes, Amadeus;Barahona, Mauricio;Clopath, Claudia
• 通讯作者: Clopath, Claudia

Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test.

• DOI: 10.1073/pnas.2107942119
• 发表时间: 2022-08-02
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1