HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION

基于血红蛋白的载氧体——设计与应用

• 批准号: 2224574
• 负责人: ENRICO BUCCI
• 金额: $ 109.99万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2224574
• 关键词: blood /plasma substitute; hemoglobin; respiratory oxygen

The development and application in vivo of artificial oxygen carriers of known and controllable characteristics offers a new approach to the exploration of uptake, delivery and utilization of oxygen by the various tissues. We will focus our efforts on the production of artificial hemoglobin-based oxygen carriers with highly controlled physico-chemical and functional properties, and test their effects on specific animal models. It is a highly interdisciplinary effort which involves molecular simulations, crystallography, genetic engineering, chemical synthesis, renal function tests and brain physiology. The strategy of the program includes two main components: Molecular design and in vivo applications.

人工氧载体的研制及其在体内的应用 已知的和可控的特性提供了一种新的方法， 探索氧气的摄取、输送和利用， 组织中 我们将集中力量生产人造 具有高度受控的物理化学性质的血红蛋白基氧载体 和功能特性，并测试其对特定动物的影响 模型 这是一个高度跨学科的努力，涉及分子 模拟，晶体学，基因工程，化学合成， 肾功能测试和脑生理学 该计划的战略 包括两个主要组成部分：分子设计和体内应用。