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HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION

HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION
基于血红蛋白的载氧体——设计与应用
批准号：
2224573
负责人：
ENRICO BUCCI
金额：
$107.96万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-08-01 至 1998-07-31
来源：
https://reporter.nih.gov/project-details/2224573
关键词：
blood /plasma substitute hemoglobin respiratory oxygen

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中文摘要
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英文摘要
The development and application in vivo of artificial oxygen carriers of known and controllable characteristics offers a new approach to the exploration of uptake, delivery and utilization of oxygen by the various tissues. We will focus our efforts on the production of artificial hemoglobin-based oxygen carriers with highly controlled physico-chemical and functional properties, and test their effects on specific animal models. It is a highly interdisciplinary effort which involves molecular simulations, crystallography, genetic engineering, chemical synthesis, renal function tests and brain physiology. The strategy of the program includes two main components: Molecular design and in vivo applications.
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TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
  • 批准号：
    6444734
  • 项目类别：
  • 资助金额：
    $29.31万
  • 财政年份：
    2001
  • 负责人：
    ENRICO BUCCI
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
TIME RESOLVED MEASUREMENTS OF CHEMICALLY MODIFIED HEMOGLOBIN
TIME RESOLVED MEASUREMENTS OF TRYPTOPHAN MUTANTS OF MYOGLOBIN
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