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TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS

TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
血红蛋白的时间分辨测量
批准号：
6315400
负责人：
ENRICO BUCCI
金额：
$2.83万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-04-01 至 2001-03-31
来源：
https://reporter.nih.gov/project-details/6315400
关键词：
biological products biomedical resource biotechnology hematology informatics spectrometry

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英文摘要
Understanding the mechanism of hemoglobin dissociation and association is a fundamental factor to study hemoglobin stability and production of hemoglobin based extracellular oxygen carriers. Clinical studies with different crosslinked and modified hemoglobins reveled symptoms which are due to fast kidney filtration and accelerated autoxidation. We are utilizing ultrafast time-resolved intrinsic tryptophan fluorescence for monitoring the hemoglobin dissociation into the dimers and monomers under high hydrostatic pressure. Our study include native human hemoglobin as well as crosslinked and mutated human and bovine hemoglobins.
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TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
  • 批准号：
    6444734
  • 项目类别：
  • 资助金额：
    $29.31万
  • 财政年份：
    2001
  • 负责人：
    ENRICO BUCCI
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
TIME RESOLVED MEASUREMENTS OF CHEMICALLY MODIFIED HEMOGLOBIN
TIME RESOLVED MEASUREMENTS OF TRYPTOPHAN MUTANTS OF MYOGLOBIN
TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
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