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HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION

HEMOGLOBIN-BASED OXYGEN CARRIERS--DESIGN AND APPLICATION
基于血红蛋白的载氧体——设计与应用
批准号:
2459981
负责人:
ENRICO BUCCI
金额:
$118.85万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-08-01 至 1999-07-31

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中文摘要
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英文摘要
The development and application in vivo of artificial oxygen carriers of known and controllable characteristics offers a new approach to the exploration of uptake, delivery and utilization of oxygen by the various tissues. We will focus our efforts on the production of artificial hemoglobin-based oxygen carriers with highly controlled physico-chemical and functional properties, and test their effects on specific animal models. It is a highly interdisciplinary effort which involves molecular simulations, crystallography, genetic engineering, chemical synthesis, renal function tests and brain physiology. The strategy of the program includes two main components: Molecular design and in vivo applications.
期刊论文(42)
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会议论文
Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit.
缺氧时的脑血流量,血细胞比容降低时血浆血红蛋白。
DOI: 10.1152/ajpheart.1998.274.6.h1933
发表时间: 1998
期刊: The American journal of physiology
影响因子: --
作者: [Ulatowski,JA, Bucci,E, Razynska,A, Traystman,RJ, Koehler,RC]
通讯作者: Koehler,RC
Molecular engineering of a polymer of tetrameric hemoglobins.
四聚血红蛋白聚合物的分子工程。
DOI: 10.1002/prot.1086
发表时间: 2001
期刊: Proteins.
影响因子: --
作者: [Fronticelli,C, Arosio,D, Bobofchak,KM, Vasquez,GB]
通讯作者: Vasquez,GB
DOI: 10.1016/s0301-4622(02)00089-3
发表时间: 2002-07
期刊: Biophysical chemistry
影响因子: 3.8
作者: [C. Fronticelli;Kevin M. Bobofchak;M. Karavitis;M. Sanna;W. S. Brinigar]
通讯作者: C. Fronticelli;Kevin M. Bobofchak;M. Karavitis;M. Sanna;W. S. Brinigar
Renal response to hemodilution with albumin or crosslinked bovine hemoglobin: role of nitric oxide.
白蛋白或交联牛血红蛋白血液稀释的肾脏反应:一氧化氮的作用。
DOI: 10.1016/s0022-2143(98)90024-5
发表时间: 1998
期刊: The Journal of laboratory and clinical medicine.
影响因子: --
作者: [Matheson,B, Razynska,A, O'Hearne,M, Bucci,E]
通讯作者: Bucci,E
34
    TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
    • 批准号:
      6444734
    • 项目类别:
    • 资助金额:
      $29.31万
    • 财政年份:
      2001
    • 负责人:
      ENRICO BUCCI
    • 依托单位:
    TIME RESOLVED MEASUREMENTS OF HEMOGLOBIN & MYOGLOBIN UNDER HYPERBARIC CONDITIONS
    TIME RESOLVED MEASUREMENTS OF CHEMICALLY MODIFIED HEMOGLOBIN
    TIME RESOLVED MEASUREMENTS OF TRYPTOPHAN MUTANTS OF MYOGLOBIN
    海外基金