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THREE-DIMENSIONAL STRUCTURE OF CYTOKINES, RECEPTORS AND IMMUNE SYSTEM PROTEINS

THREE-DIMENSIONAL STRUCTURE OF CYTOKINES, RECEPTORS AND IMMUNE SYSTEM PROTEINS
细胞因子、受体和免疫系统蛋白的三维结构
批准号：
3754227
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3754227
关键词：
X ray crystallography abzyme antibody cytokine receptors immune complex interleukin 2 lysozyme porphyrins protein structure transforming growth factors

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中文摘要
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英文摘要
1) Small crystals have been obtained for the low affinity complex of the cytokine,human Il-2 and its receptor, IL-2R-alpha. 2) The crystal structure of a catalytic antibody that catalyses a porphyrin metallation reaction has been determined. 3) The TGF-beta previously determined by us has been shown to belong to an extensive superfamily of "cystine-knot" cytokines. 4) The complex of HyHEL-5 Fab with various lysozymes have been crystallized.
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