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ENZYME STRUCTURE

ENZYME STRUCTURE
酶结构
批准号：
3854856
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3854856
关键词：
DNA binding protein X ray crystallography Xenopus crystallization enzyme complex enzyme inhibitors enzyme mechanism enzyme structure mutant nuclear magnetic resonance spectroscopy pepsin tryptophan synthase

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中文摘要
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英文摘要
1) Several data sets of the tryptophan synthase crystals from Salmonella typhimurium have been refined. The refined structures have confirmed the original observation at lower resolution of a tunnel for the passage of indole generated in the first reaction to the active site of the second enzyme. Mutants are being examined with a view to elucidating the dynamic nature of this tunnel and of the site interaction in the complex. 2) Inhibitor complexes of rhizopus pepsin have been analyzed by X- ray diffraction with a view to obtaining more information concerning the mechanism of action. 3) A method has been developed for the joint refinement of structures determined by X-ray diffraction and by NMR. 4) Crystals have been obtained for the complex of a Y-box protein from Xenopus oocytes with a DNA oligomer.
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THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM
CYTOKINES, RECEPTORS AND IMMUNE SYSTEM PROTEINS--DNA STRUCTURES
ENZYME STRUCTURE
ENZYME STRUCTURE
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