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THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM

THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM
免疫系统蛋白质的三维结构
批准号:
3964527
负责人:
D R DAVIES
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
High resolution (2A) X-ray diffraction data have been measured for J539. This will greatly extend the structure analysis of this Galactan-building Fab. High resolution X-ray data have been measured for the Fabs of two monoclonal antibodies to lysozyme complexed to lysozyme. A molecular replacement analysis of these structures is in progress. Some structural factors relating to antibody assembly have been analyzed. In particular, the nature of the interaction between CH1 and CL has been studied. A proposed model for the structure of the IgE Fc has been constructed.
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