AIDS RELATED PROTEINS--STRUCTURE AND FUNCTION

艾滋病相关蛋白质——结构和功能

• 批准号: 3854956
• 负责人: D R DAVIES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3854956
• 关键词: CD4 molecule; X ray crystallography; crystallization; electron density; enzyme structure; human immunodeficiency virus; protein structure function; ribonuclease III; surface antigens; virus protein

1) Crystals of the Rnase H from HIV have been investigated. The crystals diffract to about 3.5A resolution. Many heavy atom derivatives have been examined in order to provide an interpretable electron density map. 2) Crystals obtained of the OKT4A/CD4 complex have been grown to X-ray dimensions. Examination of these crystals showed that they do not diffract to atomic resolution. The crystallization conditions for the HIV integrase protein are being investigated.

1)对HIV核糖核酸酶H的晶体进行了研究。这个 晶体的衍射率约为3.5A。许多重原子 为了提供一种可解释的解释，对衍生品进行了研究 电子密度图。 2)获得的OKT4A/CD4复合体的晶体已经生长到 X射线尺寸。对这些晶体的检查表明，它们并没有 绕射到原子分辨率。人类免疫缺陷病毒的结晶条件 整合酶蛋白正在研究中。