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ENZYME STRUCTURE

ENZYME STRUCTURE
酶结构
批准号：
3776343
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3776343
关键词：
Salmonella typhimurium X ray crystallography active sites enzyme complex enzyme mechanism enzyme structure mutant tryptophan synthase

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中文摘要
翻译
沙门氏菌的多酶复合物，色氨酸合成酶
英文摘要
The multi-enzyme complex, tryptophan synthase from Salmonella typhimurium, has been further analyzed by X-ray diffraction. High resolution data have been collected for two derivatives of a mutant, K87T, of the beta subunit that approximate enzyme catalyzed intermediates. These structures have been refined, to provide new information about the disposition of residues and their interaction with the intermediates of the beta reaction. In addition another mutant, alpha60E, has been analyzed and data have been collected for two inhibitor complexes of the betaK87T mutant to examine the effect on flexible regions of the alpha active site.
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