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ENZYME STRUCTURE

ENZYME STRUCTURE
酶结构
批准号：
3776343
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3776343
关键词：
Salmonella typhimurium X ray crystallography active sites enzyme complex enzyme mechanism enzyme structure mutant tryptophan synthase

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中文摘要
翻译
沙门氏菌的多酶复合体色氨酸合成酶 用X-射线衍射仪对其进行了进一步分析。高 已经收集了一个突变体的两个衍生物的分辨率数据， K87T，类似酶催化的β亚基 中间体。这些结构经过了改进，以提供新的 关于残留物的处置及其与 贝塔反应的中间产物。另外还有一个突变体， 对Alpha60E进行了分析，并收集了两个 BetaK87T突变体抑制物复合体的研究 阿尔法活动部位的灵活区域。
英文摘要
The multi-enzyme complex, tryptophan synthase from Salmonella typhimurium, has been further analyzed by X-ray diffraction. High resolution data have been collected for two derivatives of a mutant, K87T, of the beta subunit that approximate enzyme catalyzed intermediates. These structures have been refined, to provide new information about the disposition of residues and their interaction with the intermediates of the beta reaction. In addition another mutant, alpha60E, has been analyzed and data have been collected for two inhibitor complexes of the betaK87T mutant to examine the effect on flexible regions of the alpha active site.
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