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THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM

THREE-DIMENSIONAL STRUCTURE OF PROTEINS OF THE IMMUNE SYSTEM
免疫系统蛋白质的三维结构
批准号：
3940693
负责人：
D R DAVIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3940693
关键词：
X ray crystallography computer simulation conformation crystallization galactans haptens immunoglobulin E immunoglobulin structure isomorphous substitution lysozyme molecular biology monoclonal antibody myeloma globulin phosphorylcholine

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中文摘要
翻译
1)对J539的高分辨率结构进行了改进。所有的 氨基酸残基已被定位，除了三个 它们看起来是无序的。 2)两种晶型的三维结构 溶菌酶与单抗Fab的复合体 对溶菌酶的影响已经确定。使用的方法是 分子置换中Fab的已知结构 和溶菌酶作为探针来确定它们的 新晶体中的取向和位置。
英文摘要
1) The high resolution structure of J539 has been refined. All the amino acid residues have been located with the exception of three that appear to be disordered. 2) The three-dimensional structure of two crystal forms of a complex between lysozyme and the Fab of a monoclonal antibody to lysozyme have been determined. The method used was molecular replacement in which the known structures of the Fab and of lysozyme were used as probes to determine their orientations and positions in the new crystal.
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