PHARMACOLOGY OF ANXIETY

A.焦虑相关行为的行为遗传学被分析 用C57BL/6J×A/J杂交种的重组近交系小鼠。都是男性 来自这两个菌株亲本系的雌性小鼠表现出 亮-暗相变模型上的大相径庭行为 焦虑、旷场测试、b-卡洛林诱发的癫痫和被动发作 回避。获得了30个重组自交系菌株(RIS)。 杰克逊实验室，缅因州巴尔港。两者的行为表型 男性和女性RIS的分布代表了C57B1/6J 行为反应的表型、A/J表型和等级 在两个极端之间。定量基因座分析，目前正在 完成，表明有四个以上的基因对 差异。 B.孕烯醇酮硫酸盐(PS)，GABA和NMDA的调节剂 感受器，在被动回避任务中被测试学习和 记忆。剂量-反应分析表明，PS单独作用不明显 但PS减弱了这种抑制作用 NMDA拮抗剂CPP对记忆的影响。

A. Behavioral genetics of an anxiety-related behavior were analyzed using recombinant inbred mice of the C57BL/6J x A/J cross. Both male and female mice from the parental lines of these two strains showed widely divergent behaviors on the light-dark transitions model of anxiety, the open field test, b-carboline-induced seizures, and passive avoidance. Thirty recombinant inbred strains,(RIS) were obtained from Jackson Laboratories, Bar Harbor, Maine. Behavioral phenotypes of both male and female RIS showed a distribution representing the C57B1/6J phenotype, the A/J phenotype, and gradations of behavioral responses between the two extremes. Quantitative loci analysis, presently being completed, suggests that more than four genes contribute to the variance. B. Pregnenolone sulfate (PS), a modulator of both the GABA and the NMDA receptors, was tested in the passive avoidance task for learning and memory. Dose-response analysis indicated that PS alone had no effect on acquisition or retention, but that PS attenuated the inhibitory effects of the NMDA antagonist, CPP, on memory.