PHARMACOLOGY OF ANXIETY

焦虑的药理学

• 批准号: 3781364
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3781364
• 关键词: aminoacid inhibitor; anxiety disorders; avoidance behavior; behavior test; behavioral genetics; convulsions; drug administration rate /duration; excitatory aminoacid; gamma aminobutyrate; genetically modified animals; laboratory mouse; learning; memory; mental disorder chemotherapy; nonhuman therapy evaluation; phenotype; pregnenolone; psychopharmacology; pyridoindole

A. Behavioral genetics of an anxiety-related behavior were analyzed using recombinant inbred mice of the C57BL/6J x A/J cross. Both male and female mice from the parental lines of these two strains showed widely divergent behaviors on the light-dark transitions model of anxiety, the open field test, b-carboline-induced seizures, and passive avoidance. Thirty recombinant inbred strains,(RIS) were obtained from Jackson Laboratories, Bar Harbor, Maine. Behavioral phenotypes of both male and female RIS showed a distribution representing the C57B1/6J phenotype, the A/J phenotype, and gradations of behavioral responses between the two extremes. Quantitative loci analysis, presently being completed, suggests that more than four genes contribute to the variance. B. Pregnenolone sulfate (PS), a modulator of both the GABA and the NMDA receptors, was tested in the passive avoidance task for learning and memory. Dose-response analysis indicated that PS alone had no effect on acquisition or retention, but that PS attenuated the inhibitory effects of the NMDA antagonist, CPP, on memory.

A.分析了一种焦虑相关行为的行为遗传学