ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS

神经精神疾病的动物模型

• 批准号: 3944709
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944709
• 关键词: alcoholism antagonist; antiadrenergic agents; appetite; benzodiazepines; brain metabolism; detoxification; eating; ethanol; hypothalamus; neurochemistry; neuropharmacology; neurotransmitter metabolism; nutrition related tag; psychopharmacology

Characterization of a benzodiazepine, Ro15-4513, which antagonizes the biochemical actions of ethanol in the rat, was performed on the behavioral test for intoxication. Other inverse agonists such as FG-7142 and beta-CCE did not block the intoxicating effects of ethanol, suggesting that Ro15-4513 acts through a mechanism which is independent of any direct behavioral effects of inverse agonists of the central benzodiazepine receptor. Preliminary assays of neuropeptides in the hypothalamus of dwarf hamsters found increased levels of NPY in separated males. Microinjection of NPY in rats is known to stimulate feeding; separated male dwarf hamsters have increased body weight.

苯二氮卓类化合物Ro 15 -4513的表征， 拮抗乙醇在大鼠体内的生化作用， 进行了行为测试 其它逆 激动剂如FG-7142和β-CCE不能阻断 乙醇的致醉作用，表明Ro 15 -4513作用于 通过独立于任何直接 中枢神经系统反向激动剂的行为效应 苯二氮卓受体 侏儒下丘脑神经肽的初步测定 仓鼠发现分开的雄性中NPY水平增加。 已知在大鼠中微量注射NPY可刺激进食; 分开的雄性矮仓鼠体重增加。