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ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS

ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS
神经精神疾病的动物模型
批准号：
3944709
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3944709
关键词：
alcoholism antagonist antiadrenergic agents appetite benzodiazepines brain metabolism detoxification eating ethanol hypothalamus neurochemistry neuropharmacology neurotransmitter metabolism nutrition related tag psychopharmacology

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英文摘要
Characterization of a benzodiazepine, Ro15-4513, which antagonizes the biochemical actions of ethanol in the rat, was performed on the behavioral test for intoxication. Other inverse agonists such as FG-7142 and beta-CCE did not block the intoxicating effects of ethanol, suggesting that Ro15-4513 acts through a mechanism which is independent of any direct behavioral effects of inverse agonists of the central benzodiazepine receptor. Preliminary assays of neuropeptides in the hypothalamus of dwarf hamsters found increased levels of NPY in separated males. Microinjection of NPY in rats is known to stimulate feeding; separated male dwarf hamsters have increased body weight.
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