ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS

神经精神疾病的动物模型

• 批准号: 3968521
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968521
• 关键词: amphetamines; anorexic agent; antidepressants; behavior disorders; behavioral medicine; benzodiazepines; brain metabolism; chemical binding; corticotropin releasing factor; cortisol; depression; detoxification; disease /disorder model; eating; ethanol; exploratory behavior; high performance liquid chromatography; hormone metabolism; interleukin 2; model design /development; nervous system disorder; neurochemistry; neurotransmitter metabolism; psychobiology; psychopharmacology; psychosis; psychosocial separation; social behavior

1) Our hamster separation model of depression was tested for changes in corticotropin releasing factor, ACTH and cortisol. 2) Mice treated chronically with steroids were tested for hyperactivity of their central dopamine pathways, both behaviorally and biochemically, as a model for steroid-induced psychoses. 3) The central hypothalamic binding site for anorectic drugs such as amphetamine was analyzed for its role in regulation of feeding behaviors. 4) A benzodiazepine which antagonizes the biochemical actions of ethanol in rat brain was found to prevent and reverse ethanol-induced intoxication in rats. 5) Behavioral analysis of rats treated chronically with interleukin-II revealed reductions in exploratory and social behaviors at doses of IL-II analogous to those which induce psychoses when used to treat cancer patients.

1)我们的仓鼠抑郁症分离模型测试了 促肾上腺皮质激素释放因子、促肾上腺皮质激素和皮质醇。 2)长期使用类固醇治疗的小鼠被测试有无多动。 他们的中枢多巴胺通路，无论是行为上还是生化上，都是一种 类固醇诱发精神病的模型。 3)厌食药物的中央下丘脑结合部位，如 分析了苯丙胺在调节摄食行为中的作用。 4)一种能拮抗乙醇的生化作用的苯二氮卓类药物 大鼠脑内可预防和逆转乙醇中毒 老鼠。 5)慢性白介素II治疗大鼠的行为学分析 发现在IL-II剂量下探索性行为和社会行为减少 类似于那些用来治疗癌症时会导致精神病的药物 病人。