课题基金 / 基金详情

NEUROPHARMACOLOGY OF ANXIETY

NEUROPHARMACOLOGY OF ANXIETY
焦虑的神经药理学
批准号：
3968520
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968520
关键词：
anxiety behavioral medicine benzodiazepines brain metabolism chlorine clinical anxiety disease /disorder model drug adverse effect ethology exploratory behavior gamma aminobutyrate learned helplessness mental disorder chemotherapy mineralocorticoids model design /development neurochemistry neuropharmacology psychobiology tranquilizer

项目摘要

项目成果

J N CRAWLEY的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Animal models of anxiety are being used to investigate the biological mechanisms underlying anxiety-related behaviors. An endogenous mineralocorticoid metabolite of progesterone, THDOC, previously characterized for its high affinity for the central benzodiazepine receptor, was tested and found to have significant anxiolytic activity in both the mouse exploratory behavior model and the Vogel thirsty-lick conflict rat model for anxiety. In addition, the anxiety component of the learned helplessness model of depression was characterized in terms of benzodiazepine, GABA, and chloride channel binding, in Sprague-Dawley and Maudsley hyperactive rats.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS
HAMSTER SEPARATION MODEL OF DEPRESSION
ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS
PHARMACOLOGY OF ANXIETY
海外基金