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NEUROPHARMACOLOGY OF ANXIETY

NEUROPHARMACOLOGY OF ANXIETY
焦虑的神经药理学
批准号：
3968520
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968520
关键词：
anxiety behavioral medicine benzodiazepines brain metabolism chlorine clinical anxiety disease /disorder model drug adverse effect ethology exploratory behavior gamma aminobutyrate learned helplessness mental disorder chemotherapy mineralocorticoids model design /development neurochemistry neuropharmacology psychobiology tranquilizer

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中文摘要
翻译
焦虑的动物模型被用来研究生物学上的 焦虑相关行为的潜在机制。 内源 孕酮盐皮质激素代谢物，THDOC，以前 以其对中心苯并二氮杂卓的高亲和力为特征 受体，进行了测试，发现有显着的抗焦虑活性， 小鼠探索行为模型和Vogel渴舔模型 冲突大鼠焦虑模型。 此外，焦虑成分的 抑郁症的习得性无助模型的特点是， 苯二氮卓类、GABA和氯离子通道结合，在Sprague-Dawley和 毛兹利多动老鼠。
英文摘要
Animal models of anxiety are being used to investigate the biological mechanisms underlying anxiety-related behaviors. An endogenous mineralocorticoid metabolite of progesterone, THDOC, previously characterized for its high affinity for the central benzodiazepine receptor, was tested and found to have significant anxiolytic activity in both the mouse exploratory behavior model and the Vogel thirsty-lick conflict rat model for anxiety. In addition, the anxiety component of the learned helplessness model of depression was characterized in terms of benzodiazepine, GABA, and chloride channel binding, in Sprague-Dawley and Maudsley hyperactive rats.
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