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NEUROPHARMACOLOGY OF ANXIETY

NEUROPHARMACOLOGY OF ANXIETY
焦虑的神经药理学
批准号：
4696462
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4696462
关键词：
anxiety benzodiazepines brain metabolism clinical anxiety disease /disorder model drug adverse effect ethology mental disorder chemotherapy model design /development neuroanatomy neurochemistry neuropharmacology psychophysiology tranquilizer

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英文摘要
Animal models of anxiety are being used to investigate the biological mechanisms underlying anxiety-related behaviors. Anatomical sites mediating responses to benzodiazepines and GABAergic drugs are being tested, using the thirsty-lick conflict model. Muscimol, 5 Mug, produced a significant anxiolytic response when microinjected into the lateral septum. Neurophysiological sensitivity to muscimol was increased in substantia nigra neurons after tailshock stress. Inescapable tailshock stress also decreased the number of 3H-Ro5-4864 binding sites in rat cerebral cortex, heart and kidney.
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HAMSTER SEPARATION MODEL OF DEPRESSION
ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS
ANIMAL MODELS OF NEUROPSYCHIATRIC DISORDERS
PHARMACOLOGY OF ANXIETY
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