PHARMACOLOGY OF ANXIETY

焦虑的药理学

• 批准号: 3921935
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921935
• 关键词: anxiety; behavioral medicine; biological models; escape reaction; ethology; genetic strain; laboratory rat; learned helplessness; memory; mood disorders; neurochemistry; psychobiology; stress

The Maudsley Reactive rat is a strain of Wistar inbred rat which shows "hyperemotionality", characterized by a high incidence of freezing and defecation in an open field. Dr. Cottingham is characterizing this strain behaviorally and biochemically. Maudsley Reactives bred in our vivarium showed the expected high levels of freezing and defecation in our open field videotracking apparatus, as compared to Maudsley Non-Reactive and Sprague-Dawley controls. However, the Reactives showed no differences on the learned helplessness syndrome, or on t-maze memory paradigms. No differences between MNR and MR strains were found in mRNA for TH in adrenal gland or locus coeruleus, in mRNA for GAD in cortex, hippocampus, cerebellum, or striatum, or in mRNA for the gamma subunit of the GABA-A receptor in cortex or hippocampus. The MR had a significantly suppressed immune function, as measured by markers for t-cell and beta-cell proliferation.

Maudsley反应鼠是Wistar近交系大鼠的一个品系 表现出“过度情绪化”，其特征是高发病率 在开阔的田野里结冰和大便。科廷厄姆医生是 对该菌株的行为和生化特征进行了研究。 在我们的中培养的Maudsley反应物显示出预期的高水平 我们野外视频跟踪中的冰冻和排便水平 仪器，与莫德斯利无反应和斯普拉格-道利比较 控制。然而，这些反动者在 习得性无助综合症，或关于t-迷宫记忆范式。不是 MNR株和MR株在基因转录水平上存在差异 在肾上腺或蓝斑，在皮质GAD的mRNA， 海马体、小脑或纹状体，或在伽马体的mRNA中 皮质或海马区GABA-A受体的亚单位。这位先生 有显著的免疫功能抑制，通过测量 T细胞和β细胞增殖的标志物。