ANIMAL MODEL OF NEUROPSYCHIATRIC DISORDERS

酪氨酸羟化酶mRNAs的原位杂交分析 胆囊素、脑啡肽、D-1和D-2多巴胺受体亚型， 和多巴胺转运蛋白，在新生大鼠的大脑中 可卡因，都快完成了。可卡因治疗没有区别 而饮食控制在腹侧的mRNA浓度中被看到 被盖、黑质、尾状核或伏隔核 TH、CCK、ENK、D-1或D-2 mRNAs。德·巴托洛米斯博士最近 开发了一种新的多巴胺转运体寡核苷酸探针， 他以特定性为特征，现在正在量化 产前可卡因实验。

In situ hybridization analysis of mRNAs for tyrosine hydroxylase, cholecystokinin, enkephalin, the D-1 and D-2 dopamine receptor subtypes, and the dopamine transporter, in brains from rats treated neonatally with cocaine, are almost completed. No difference between cocaine treatment and dietary controls has been seen in mRNA concentrations in the ventral tegmentum, substantia nigra, caudate nucleus, or nucleus accumbens, for TH, CCK, ENK, D-1, or D-2 mRNAs. Dr. de Bartolomeis has recently developed a new oligonucleotide probe for the dopamine transporter, which he has characterized for specificity, and is now quantitating in the prenatal cocaine experiment.