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ANIMAL MODEL OF NEUROPSYCHIATRIC DISORDERS

ANIMAL MODEL OF NEUROPSYCHIATRIC DISORDERS
神经精神疾病的动物模型
批准号：
3845218
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3845218
关键词：
brain metabolism caudate nucleus cholecystokinin cocaine disease /disorder model dopamine receptor enkephalins in situ hybridization infant animal laboratory rat membrane transport proteins messenger RNA method development model design /development nervous system disorder nucleic acid probes nucleus accumbens substantia nigra tegmentum tyrosine 3 monooxygenase

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中文摘要
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英文摘要
In situ hybridization analysis of mRNAs for tyrosine hydroxylase, cholecystokinin, enkephalin, the D-1 and D-2 dopamine receptor subtypes, and the dopamine transporter, in brains from rats treated neonatally with cocaine, are almost completed. No difference between cocaine treatment and dietary controls has been seen in mRNA concentrations in the ventral tegmentum, substantia nigra, caudate nucleus, or nucleus accumbens, for TH, CCK, ENK, D-1, or D-2 mRNAs. Dr. de Bartolomeis has recently developed a new oligonucleotide probe for the dopamine transporter, which he has characterized for specificity, and is now quantitating in the prenatal cocaine experiment.
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