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HAMSTER SEPARATION MODEL OF DEPRESSION

HAMSTER SEPARATION MODEL OF DEPRESSION
仓鼠抑郁症分离模型
批准号：
4696463
负责人：
J N CRAWLEY
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4696463
关键词：
MAO inhibitors amphetamines antidepressants behavior disorders body weight brain metabolism chemical binding depression disease /disorder model eating exploratory behavior gender difference glucose metabolism high performance liquid chromatography model design /development neurochemistry neurotransmitter metabolism psychophysiology psychosocial separation serotonin social behavior

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英文摘要
A novel hamster separation model of depression is under development for analysis of central neurochemical changes during a behavior state of separation which may be analogous to human depression. Separated male dwarf hamsters show increased body weight, decreased exploratory behaviors, and reduced social interactions. High pressure liquid chromatography assays of brain monoamines and metabolites failed to detect significant differences in separated hamsters as compared to hamsters remaining in male-female pairs. Autoradiographic assays of opiate receptors failed to detect significant differences between separated and paired hamsters on 3H-naloxone binding.
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