HAMSTER SEPARATION MODEL OF DEPRESSION

仓鼠抑郁症分离模型

• 批准号: 4696463
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696463
• 关键词: MAO inhibitors; amphetamines; antidepressants; behavior disorders; body weight; brain metabolism; chemical binding; depression; disease /disorder model; eating; exploratory behavior; gender difference; glucose metabolism; high performance liquid chromatography; model design /development; neurochemistry; neurotransmitter metabolism; psychophysiology; psychosocial separation; serotonin; social behavior

A novel hamster separation model of depression is under development for analysis of central neurochemical changes during a behavior state of separation which may be analogous to human depression. Separated male dwarf hamsters show increased body weight, decreased exploratory behaviors, and reduced social interactions. High pressure liquid chromatography assays of brain monoamines and metabolites failed to detect significant differences in separated hamsters as compared to hamsters remaining in male-female pairs. Autoradiographic assays of opiate receptors failed to detect significant differences between separated and paired hamsters on 3H-naloxone binding.

一种新的抑郁症仓鼠分离模型正在开发中， 分析行为状态下的中枢神经化学变化 分离可能类似于人类抑郁症。 分居男性 侏儒仓鼠显示体重增加，探索行为减少， 减少了社会交往。 高压液相色谱 脑单胺和代谢物的测定未能检测到显著的 分离的仓鼠与留在 男女配对 阿片受体的放射自显影分析未能 检测分离和配对仓鼠之间的显著差异， 3 H-纳洛酮结合。