PHARMACOLOGY OF ANXIETY

焦虑的药理学

• 批准号: 3845217
• 负责人: J N CRAWLEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3845217
• 关键词: anxiety; behavioral medicine; convulsions; diazepam; ethology; genetic strain; laboratory mouse; pentylenetetrazole; psychopharmacology; recombinant DNA; regulatory gene; tranquilizer

Genetic analysis of anxiety-related behaviors has begun for recombinant inbred strains of the C57Bl/6J x A/J cross. A screen of mouse strains showed the biggest behavioral differences between the C57Bl/6J and the A/J from Jackson Labs. This cross is also a good choice because 30 RI strains are maintained at Jackson from this cross. Baseline light-dark transitions, increase in transitions after diazepam, open field ambulation, were found to be high in the C57Bl/6J and low in the A/J. The A/J were more sensitive to pentylenetetrazol and to B-CCM on induction of seizures. Behavioral testing on these parameters has been completed for 11 RI strains, 9 are partially tested, and the remaining strains are now arriving, to create a data base sufficient for statistical analysis of number of genes which may be mediating anxiety-related behaviors in mice.

焦虑相关行为的遗传分析已经开始， C57 B1/6 J X A/J杂交的近交系。 小鼠品系筛选 C57 Bl/6 J和A/J之间的行为差异最大 杰克逊实验室的 这种杂交也是一个很好的选择，因为30个RI菌株 从这个十字路口一直保持在杰克逊。 基线明暗 转换，地西泮后转换增加，开放视野 在C57 B1/6 J中，A10蛋白表达量高，而在A/J中表达量低。 A/J对戊四氮和B-CCM的诱导作用更敏感， 癫痫发作 这些参数的行为测试已经完成， 11个RI菌株，9个部分测试，其余菌株现在 到达，创建足以进行统计分析的数据库 可能介导小鼠焦虑相关行为的基因数量。