SYMPATHOADRENAL AND CATECHOLAMINERGIC FUNCTION IN HEALTH AND DISEASE

健康和疾病中的交感肾上腺和儿茶酚胺能功能

• 批准号: 3782423
• 负责人: D S GOLDSTEIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3782423
• 关键词: adrenal medulla; alpha adrenergic receptor; catecholamines; dopamine; glucocorticoids; heart disorder diagnosis; heart function; heart innervation; homeostasis; human subject; laboratory rat; microdialysis; neural transmission; neurochemistry; neuroendocrine system; neurotransmitter biosynthesis; noninvasive diagnosis; norepinephrine; physiologic stressor; positron emission tomography; spontaneous hypertensive rat; stress; sympathetic nervous system

Our laboratory develops and applies methods for assessing the function of central and peripheral catecholaminergic systems and the coordination of these systems with other homeostatic systems in health, stress, and disease. Findings this year include: (1) Position-emission tomographic (PET) scanning after systemic administration of 6-[18F]fluorodopamine ([18F]-6F-DA) provided a noninvasive, in vivo means to examine cardiac sympathetic innervation and function in humans. (2) Clinical microneuro- graphic and tracer norepinephrine (NE) kinetic methods were applied to diagnose neurocardiologic disorders, test the "epinephrine hypothesis" of sympathetic neurotransmission, and assess catechol~aminergic effects of glucocorticoids in humans. (3) In vivo microdialysis revealed juvenile spontaneously hypertensive rats have increased alpha2-adrenoceptor- mediated restraint of catecholamine biosynthesis and NE release in the posterolateral hypothalamus. (4) Patterning of neuroendocrine responses has supported a homeostat theory of stress.

我们实验室开发并应用了评估功能的方法 中枢儿茶酚胺能系统和外周儿茶酚胺能系统的协调 这些系统与其他动态平衡系统在健康、压力和 疾病。今年的发现包括：(1)位置发射断层扫描 全身注射6-[18F]氟多巴胺后的(PET)扫描 ([18F]-6F-DA)提供了一种无创的、活体检查心脏的方法 人类的交感神经支配和功能。(2)临床微欧元- 采用图形和示踪剂去甲肾上腺素(NE)动力学方法 诊断神经性心脏病，测试肾上腺素假说 交感神经传递，并评估儿茶酚~胺能作用 人类体内的糖皮质激素。(3)体内微透析揭示青少年 自发性高血压大鼠α2肾上腺素能受体增加 介导的儿茶酚胺生物合成抑制和去甲肾上腺素释放 下丘脑后外侧。(4)神经内分泌反应模式 支持压力的稳态理论。