PLASMA CATECHOLAMINES AND SYMPATHETIC ACTIVITY IN CLINICAL HYPERTENSION

临床高血压中的血浆儿茶酚胺和交感神经活动

• 批准号: 4694562
• 负责人: D S GOLDSTEIN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694562
• 关键词: cardiovascular disorder; cardiovascular disorder diagnosis; clonidine; drug hypersensitivity; human subject; hypertension; isoproterenol; neurotransmitter metabolism; norepinephrine; plasma; postural hypotension; sympathectomy; sympathetic nervous system; synapses

We have used concentrations of plasma catecholamines to indicate activity of the sympathetic nervous system (SNS) in patients with essential hypertension, orthostatic hypotension, the hyperdynamic circulatory state syndrome, or sympathectomies. We developed clinical methods to estimate synaptic cleft concentrations of norepinephrine (NE), the sympathetic neurotransmitter; neuronal NE uptake (Uptake-1); and regional NE removal. We used clonidine suppression testing to identify patients in whom increased SNS activity contributed to high blood pressure. Measurement of arterial and venous NE in sympathectomized and intact human limbs confirmed the validity of plasma NE to indicate SNS activity. Patients with idiopathic orthostatic hypotension had decreased Uptake-1 activity. Elevated plasma catecholamines, clonidine sensitivity, and excessive responsiveness to isoproterenol characterized a patient with hyperdynamic circulaion syndrome. The amount of release of endogenous NE during isoproterenol infusions may indicate pre-synaptic beta adrenoceptor responsiveness. Dopamine does not act as a natriuretic hormone.

我们使用血浆儿茶酚胺浓度来指示活性 患有原发性心脏病的患者交感神经系统（SNS）的变化 高血压、体位性低血压、高动力循环状态 综合症或交感神经切除术。 我们开发了临床方法来估计 去甲肾上腺素（NE）的突触间隙浓度，交感神经 神经递质；神经元 NE 摄取（Uptake-1）；和区域 NE 去除。 我们使用可乐定抑制试验来识别患有以下疾病的患者： SNS 活动增加会导致高血压。 测量 证实在交感神经切除和完整的人体四肢中存在动脉和静脉 NE 血浆 NE 指示 SNS 活性的有效性。 患者患有 特发性直立性低血压导致 Uptake-1 活性降低。 血浆儿茶酚胺、可乐定敏感性升高和过量 高动力患者对异丙肾上腺素的反应特征 循环综合症。 内源性NE释放量 异丙肾上腺素输注可能表明突触前β肾上腺素能受体 反应能力。 多巴胺不充当利尿钠激素。