PLASMA CATECHOLAMINES AND SYMPATHETIC ACTIVITY IN CLINICAL HYPERTENSION

我们用血浆中儿茶酚胺的浓度来表示活性 交感神经系统（SNS）在原发性 高血压，体位性低血压，高动力循环状态 综合征或交感神经切除术。 我们开发了临床方法来估计 突触间隙中去甲肾上腺素（NE）、交感神经 神经递质;神经元NE摄取（Uptake-1）;和区域NE去除。 我们使用可乐定抑制试验来识别 增加SNS活动有助于高血压。 测量 交感神经切除和完整的人肢体动脉和静脉NE证实 血浆去甲肾上腺素（NE）对SNS活性的指示作用。 患者 特发性直立性低血压患者Uptake-1活性降低。 血浆儿茶酚胺升高，可乐定敏感性，以及过量 对异丙肾上腺素的反应性表现为高动力性 循环综合征 内源性NE的释放量 注射异丙肾上腺素可能提示突触前β肾上腺素受体 响应能力。 多巴胺不作为一种利钠激素。

We have used concentrations of plasma catecholamines to indicate activity of the sympathetic nervous system (SNS) in patients with essential hypertension, orthostatic hypotension, the hyperdynamic circulatory state syndrome, or sympathectomies. We developed clinical methods to estimate synaptic cleft concentrations of norepinephrine (NE), the sympathetic neurotransmitter; neuronal NE uptake (Uptake-1); and regional NE removal. We used clonidine suppression testing to identify patients in whom increased SNS activity contributed to high blood pressure. Measurement of arterial and venous NE in sympathectomized and intact human limbs confirmed the validity of plasma NE to indicate SNS activity. Patients with idiopathic orthostatic hypotension had decreased Uptake-1 activity. Elevated plasma catecholamines, clonidine sensitivity, and excessive responsiveness to isoproterenol characterized a patient with hyperdynamic circulaion syndrome. The amount of release of endogenous NE during isoproterenol infusions may indicate pre-synaptic beta adrenoceptor responsiveness. Dopamine does not act as a natriuretic hormone.