COLLABORATIVE STUDIES OF NEUROENDOCRINE CIRCULATORY CONTROL

我们与其他几个小组合作研究神经内分泌 控制流通。 我们开发了第一个灵长类动物模型， DOCA/盐性高血压。 这种形式的高血压与 血浆儿茶酚胺水平升高，并且对 肾上腺素能阻滞剂，但对利尿剂敏感。 长期重复 操作性舒张压引起的升压发作 调节只是不一致地产生持续的血液增加， 狒狒的压力 我们发现了功能性的证据 肾上腺髓质上的促肾上腺皮质激素释放激素（CRF）受体， 交感神经节细胞 在接受绵羊CRF的人类受试者中， 吗啡减弱ACTH对CRF的反应，而不影响血浆 儿茶酚胺或加压素。 在接受第三磨牙手术的受试者中 提取物，血浆肾上腺素的增加大于去甲肾上腺素（NE） 观察了 免疫反应性β-内啡肽增加， 芬太尼阻滞手术，不影响儿茶酚胺 反应 真菌毒素T-2的施用， 休克，与高儿茶酚胺水平有关，显然是由于乳酸 酸中毒 肾内输注心钠素（ANF） 影响狗尿中去甲肾上腺素或多巴胺的产生。 ANF出现 以抑制差异性α肾上腺素受体亚型。

We have collaborated with several other groups in studies of neuroendocrine control of the circulation. We developed the first primate model for DOCA/salt hypertension. This form of hypertension is not associated with elevated levels of plasma catecholamines, and it is insensitive to adrenergic blockers but sensitive to diuretics. Chronically repeated pressor episodes resulting from operant diastolic blood pressure condditioning only inconsistently produced sustained increases in blood pressure in baboons. We found evidence for functional corticotropin-releasing hormone (CRF) receptors on adrenomedullary and sympathetic ganglionic cells. In human subjects who received ovine CRF, morphine blunted the ACTH response to CRF without affecting plasma catecholamines or vasopressin. In subjects undergoing third molar extractions, larger inreases in plasma epinephrine than norepinephrine (NE) were observed. Increases in immunoreactive beta-endorphin during the surgery were blocked by fentanyl without affected the catecholamine response. Administration of the mycotoxin, T-2, produces circulatory shock, associated with high catecholamine levels, apparently due to lactic acidosis. Intrarenal infusion of atrial natriuretic factor (ANF) did not affect urinary norepinephrine or dopamine production in dogs. ANF appears to inhibit differentially alpha adrenoceptor subtypes.