SYMPATHOADRENAL AND CATECHOLAMINE FUNCTION IN HEALTH

健康中的交感肾上腺和儿茶酚胺功能

• 批准号: 6163057
• 负责人: D S GOLDSTEIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6163057
• 关键词: Menkes' syndrome; Parkinson's disease; catecholamines; clinical research; congestive heart failure; disease /disorder classification; dopamine; epinephrine; familial dysautonomia; gastrointestinal system; homeostasis; hormone regulation /control mechanism; human subject; neurochemistry; neuroendocrine system; neuroregulation; neurotransmitter biosynthesis; norepinephrine; perfusion; peripheral nervous system disorders; positron emission tomography; postural hypotension; prodrugs; sympathetic nervous system; syncope

Catecholamine systems, operating at the interface between the mind and the body, exemplify three ways the brain regulates homeostasis -- via neurotransmitters (norepinephrine, NE), hormones (epinephrine, EPI), and autocrine/paracrine factors (dopamine, DA). We conducted investigations in the areas of clinical neurocardiology, catecholamine neurochemistry, and novel catecholaminergic systems. 6-[18F]fluorodopamine ([18F]-6F-DA) positron-emission tomographic (PET) scanning led to a new pathophysiological classification of primary chronic autonomic failure. Patients with pure autonomic failure (PAF) or parkinsonism and autonomic failure had cardiac sympathetic denervation, whereas patients with the Shy-Drager syndrome had decreased or absent post-ganglionic sympathetic neural outflows to intact nerve terminals. 13N-ammonia and [18F]-6F-DA PET scanning detected perfusion or sympathoneural abnormalities in the affected limbs of patients with sympathetic dystrophy (RSD). Patients prone to neurocardiogenic syncope had decreased cardiac NE spillover, and patients with hypertrophic cardiomyopathy (HCM) had intact sympathetic innervation of the hypertrophic myocardium. Clinical neurochemical studies linked specific catecholaminergic phenotypes with genotypic abnormalities in Menkes' disease, familial dysautonomia (FD), and L-aromatic-amino-acid decarboxylase (LAAAD) deficiency. Treatment with L-DOPA as a dopaminergic pro-drug produced beneficial natriuretic responses in patients with congestive heart failure. Plasma DA-sulfate levels were found to depend on dietary factors and on production of endogenous DA in the gastrointestinal tract.

儿茶酚胺系统，在大脑和大脑之间的界面上运行 身体，例证了大脑调节动态平衡的三种方式--通过 神经递质(去甲肾上腺素，NE)、激素(肾上腺素，EPI)和 自分泌/旁分泌因子(多巴胺、多巴胺)。我们在以下方面进行了调查 临床神经心脏病学、儿茶酚胺神经化学和 新型儿茶酚胺能系统。6-[18F]氟多胺([18F]-6F-DA) 正电子发射断层扫描(PET)导致了一种新的 原发性慢性自主神经衰竭的病理生理分类。 单纯自主神经衰竭(PAF)或帕金森病合并自主神经的患者 衰竭会导致心脏交感神经丧失，而患有心力衰竭的患者 Shy-Drager综合征节后交感神经减少或缺失 神经流出到完整的神经末梢。13N-氨和[18F]-6F-DA PET 扫描检测到脑血流灌注或交感神经异常。 交感神经营养不良(RSD)患者患肢。病人 易发生神经性心源性晕厥的患者心脏去甲肾上腺素外溢减少，且 肥厚型心肌病(HCM)患者的交感神经完整 肥大心肌的神经支配。临床神经化学研究 特异儿茶酚胺能表型与基因异常相关 家族性自主神经功能障碍与L芳香族氨基酸 脱羧酶(LAAAD)缺乏症。L多巴作为多巴胺能药的治疗 前体药物在慢性阻塞性肺疾病患者中产生有益的利钠反应 充血性心力衰竭研究发现，血浆DA-硫酸盐水平依赖于 饮食因素与胃肠道内源性多巴胺的产生 一条小路。