SYMPATHOADRENAL AND CATECHOLAMINE FUNCTION IN HEALTH

健康中的交感肾上腺和儿茶酚胺功能

• 批准号: 6111886
• 负责人: D S GOLDSTEIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6111886
• 关键词: Menkes' syndrome; Parkinson's disease; catecholamines; clinical research; congestive heart failure; disease /disorder classification; dopamine; epinephrine; familial dysautonomia; gastrointestinal system; homeostasis; hormone regulation /control mechanism; human subject; neurochemistry; neuroendocrine system; neuroregulation; neurotransmitter biosynthesis; norepinephrine; perfusion; peripheral nervous system disorders; positron emission tomography; postural hypotension; prodrugs; sympathetic nervous system; syncope

Catecholamine systems, operating at the interface between the mind and the body, exemplify three ways the brain regulates homeostasis -- via neurotransmitters (norepinephrine, NE), hormones (epinephrine, EPI), and autocrine/paracrine factors (dopamine, DA). We conducted clinical investigations in neurocardiology, catecholamine neurochemistry, and novel catecholaminergic systems. 6-[18F]fluorodopamine ([18F]-6F- DA) positron-emission tomographic (PET) scanning led to a new pathophysiological classification of primary chronic autonomic failure. Patients with pure autonomic failure (PAF) or parkinsonism and autonomic failure had cardiac sympathetic denervation, whereas patients with the Shy-Drager syndrome had decreased post-ganglionic sympathetic neural outflows to intact nerve terminals. 13N-ammonia and [18F]-6F-DA PET scanning detected perfusion or sympathoneural abnormalities in the affected limbs of patients with sympathetic dystrophy (RSD). Patients with a history of repeated episodes of neurocardiogenic syncope had decreased cardiac NE spillover, and patients with hypertrophic cardiomyopathy (HCM) had evidence for decreased neuronal uptake of NE in the hypertrophic myocardium. Neurochemical studies linked specific catecholaminergic phenotypes with genotypic abnormalities in Menkes' disease, familial dysautonomia (FD), and L-aromatic-amino-acid decarboxylase (LAAAD) deficiency. Treatment with L-DOPA as a dopaminergic pro-drug produced beneficial natriuretic responses in patients with congestive heart failure. Plasma DA-sulfate levels were found to depend on dietary factors and on production of endogenous DA in the gastrointestinal tract.

儿茶酚胺系统，在界面上运行 在思想和身体之间，举例说明大脑的三种方式 通过神经递质（去甲肾上腺素、 NE）、激素（肾上腺素、EPI）和自分泌/旁分泌因子 （多巴胺，DA）。我们进行了临床研究 神经心脏病学、儿茶酚胺神经化学和新颖 儿茶酚胺能系统。 6-[18F]氟多巴胺 ([18F]-6F-DA) 正电子发射断层扫描（PET）扫描带来了新的 原发性慢性植物神经病的病理生理学分类 失败。纯自主神经衰竭 (PAF) 或帕金森症患者 自主神经衰竭导致心脏交感神经失控， 而患有 Shy-Drager 综合征的患者则减少了 节后交感神经流出至完整神经 终端。 PET 扫描检测到 13N-氨和 [18F]-6F-DA 受影响肢体的灌注或交感神经异常 交感神经营养不良（RSD）患者。有病史的患者 神经心源性晕厥反复发作的次数有所减少 心脏 NE 溢出和肥厚患者 心肌病（HCM）有神经元减少的证据 肥厚心肌中 NE 的摄取。神经化学 研究将特定儿茶酚胺能表型与基因型联系起来 门克斯病、家族性自主神经功能异常 (FD) 异常和 L-芳香氨基酸脱羧酶（LAAAD）缺乏。 用 L-DOPA 作为多巴胺能前药进行治疗 充血性心脏病患者有益的利尿钠反应 失败。研究发现血浆 DA-硫酸盐水平取决于饮食 胃肠道内源性DA产生的影响因素 道。