PLASMA CATECHOLAMINES AND SYMPATHETIC ACTIVITY IN CLINICAL HYPERTENSION

临床高血压中的血浆儿茶酚胺和交感神经活动

• 批准号: 3966596
• 负责人: D S GOLDSTEIN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3966596
• 关键词: cardiovascular disorder; cardiovascular disorder diagnosis; clonidine; disease /disorder proneness /risk; human subject; hypertension; isoproterenol; neuropharmacology; neurotransmitter metabolism; norepinephrine; plasma; postural hypotension; stress; sympathectomy; sympathetic nervous system; synapses

We have developed and applied methodology for measuring regional and total body release and neuronal uptake of norepinephrine (NE), the sympathetic neurotransmitter, and have assessed the effects of various stimuli (isoproterenol, clonidine, manipulations of dietary salt) on sympathetic activity. Total body spillover of NE into the circulation is increased by playing an electronic game, which also increases blood pressure, pulse rate, cardiac output, and forearm blood flow. Applying these methods to patients with essential hypertension should allow testing of the long-standing hypothesis that excessive sympathetic responses to mental challenge characterizes young patients with hypertension or subjects at risk for developing established hypertension. The clonidine suppression test can be conducted without controlling dietary salt intake and can be used to define the neurogenic contribution to hypertension. Isoproterenol stimulates NE release without affecting plasma epinephrine (E) and may therefore be helpful in studying pre-synaptic beta-adrenoceptor function in hypertensive patients. Circulating beta-adrenoceptor agonists do not increase adrenocorticotropin (ACTH).

我们已经开发并应用了衡量区域和总量的方法