PLASMA CATECHOLAMINES AND SYMPATHETIC ACTIVITY IN CLINICAL HYPERTENSION

我们开发并应用了衡量区域和总体的方法 身体释放和神经元摄取去甲肾上腺素（NE），交感神经 神经递质，并评估了各种刺激的影响， （异丙肾上腺素，可乐定，膳食盐的操作）对交感神经系统的影响 活动 NE进入循环的全身溢出增加， 玩电子游戏，也会增加血压，脉搏 心率、心输出量和前臂血流量。 将这些方法应用于 原发性高血压患者应允许检测 长期存在的假设是，过度的交感神经反应， 挑战的特点是年轻的高血压患者或受试者， 发展为高血压的风险。 可乐定抑制 测试可以在不控制饮食盐摄入的情况下进行， 用于定义神经源性对高血压的影响。 异丙 刺激NE释放而不影响血浆肾上腺素（E）， 因此有助于研究突触前β-肾上腺素受体的功能， 高血压患者。 循环β-肾上腺素受体激动剂不 促肾上腺皮质激素（ACTH）升高。

We have developed and applied methodology for measuring regional and total body release and neuronal uptake of norepinephrine (NE), the sympathetic neurotransmitter, and have assessed the effects of various stimuli (isoproterenol, clonidine, manipulations of dietary salt) on sympathetic activity. Total body spillover of NE into the circulation is increased by playing an electronic game, which also increases blood pressure, pulse rate, cardiac output, and forearm blood flow. Applying these methods to patients with essential hypertension should allow testing of the long-standing hypothesis that excessive sympathetic responses to mental challenge characterizes young patients with hypertension or subjects at risk for developing established hypertension. The clonidine suppression test can be conducted without controlling dietary salt intake and can be used to define the neurogenic contribution to hypertension. Isoproterenol stimulates NE release without affecting plasma epinephrine (E) and may therefore be helpful in studying pre-synaptic beta-adrenoceptor function in hypertensive patients. Circulating beta-adrenoceptor agonists do not increase adrenocorticotropin (ACTH).