CLINICAL PHYSIOLOGY OF HYPERTENSION

我们测量了原发性高血压患者的压力反射-心脏敏感性， 高血压和高动力循环综合征。 我们注意到 患者的压力反射敏感性，与 压力反射敏感性和血浆去甲肾上腺素。 我们已经使用 激光多普勒血流仪显示无反射性皮肤 局部交感神经切除术患者的微血管反应。 皮肤微血管血流的自发振荡被观察到， 切除交感神经的人类肢体 我们测试了阻抗的有效性 用于心输出量和中风的无创测量的心动描记术 通过比较阻抗技术与侵入性手术的体积。 我们 正在开发一种多普勒超声方法，用于连续测量 血管流动和扩张性。 我们测试了一个循环模型， 预测肱动脉压力波形的变化， 血管收缩和血管舒张。 年轻的患者， 高血压对肱动脉重搏的调节有缺陷 波，该模型解释为动脉硬度增加， 血管舒张反应性降低。

We have measured baroreflex-cardiac sensitivity in patients with essential hypertension and the hyperdynamic circulation syndrome. We noted decreased baroreflex sensitivity in the patients, with an inverse correlation between baroreflex sensitivity and plasma norepinephrine. We have used laser-Doppler flowmetry to demonstrate the absence of reflexive skin microvascular responses in patients with regional sympathectomies. Spontaneous oscillations in skin microvascular flow were observed in the sympathectomized human limbs. We tested the validity of impedance cardiography for non-invasive measurement of cardiac output and stroke volume by comparing the impedance technique with invasive procedures. We are developing a Doppler-ultrasound method for continuous measurements of vascular flow and distensibility. We have tested a circulatory model which predicts the changes in the brachial artery pressure waveform during vasoconstriction and vasodilation. Young patients with essential hypertension have defective modulation of the brachial arterial dicrotic wave, which the model explains in terms of increased arterial rigidity and decreased vasodilator responsiveness.