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CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS

CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
DNA/蒽环类药物相互作用的量热研究
批准号：
3789399
负责人：
C P MUDD
金额：
$0.0万
依托单位：
NATIONAL CENTER FOR RESEARCH RESOURCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3789399
关键词：
DNA anthracyclines calorimetry chemical binding drug interactions ionic strengths stop flow technique temperature thermodynamics

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英文摘要
After performing the first direct measurements of the binding enthalpies of the anthracycline drug daunomycin to DNA in the 10 to 20 micromolar range (where the monomeric form predominates), we extended the experiment to study the interaction with other DNA hosts at varying salt concentrations and temperatures. With a differential stopped-flow microcalorimeter, we were able to measure 120 of these enthalpies per day, with an uncertainty of only 3 microjoules. The enthalpy heats ranged from -20 microjoules (endothermic) to +50 microjoules (exothermic). The experiments have now been expanded to measure and compare a complete set of binding profiles for a series of DNA host complexes.
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TEMPERATURE CONTROLLED CHAMBER FOR X-RAY DIFFRACTION SPECIMENS
  • 批准号：
    3959937
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C P MUDD
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
HIGH-SPEED DIFFERENTIAL STOPPED-FLOW CALORIMETER
SIGNAL CONDITIONING & DATA ACQUISITION SYSTEM FOR SLEEP DEPRIVATION STUDIES
CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
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