寄生虫病的生理和细胞化学病理学-猫眼课题宝

寄生虫病的生理和细胞化学病理学

批准号：

3790661

负责人：

T I MERCADO

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3790661

关键词：

Pseudomonas Trypanosoma cruzi antiprotozoal agents chemical structure gel filtration chromatography high performance liquid chromatography histochemistry /cytochemistry mass spectrometry nuclear magnetic resonance spectroscopy trypanosomiasis

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英文摘要

Studies on the purification and chemical characterization of a lytic, anti-trypanosomal factor (ATF-II) from the bacterial species, Pseudomonas fluorescens, were continued. Elemental microanalysis, reversed-phase high performance liquid chromatography (HPLC), Sephadex gel filtration, gel electrophoresis, fast atom bombardment mass spectroscopy (FAB), and nuclear magnetic resonance spectroscopy (NMR) were employed. The purified ATF-II consists of three main components, an alpha-d-glycoside, a peptide, and a component that was not identified, but appears to be a contaminant. More precise HPLC is being used to eliminate this fraction and facilitate an exact determination of the chemical structure. The determination of the chemical structure is essential before studies on synthesis are initiated and pharmacological and toxicological properties are examined employing Trypanosoma cruzi infections.

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