寄生虫病的生理和细胞化学病理学-猫眼课题宝

寄生虫病的生理和细胞化学病理学

批准号：

3818104

负责人：

T I MERCADO

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3818104

关键词：

Pseudomonas Trypanosoma Trypanosoma cruzi antiprotozoal agents drug design /synthesis /production high performance liquid chromatography histochemistry /cytochemistry laboratory mouse nuclear magnetic resonance spectroscopy parasitic disease chemotherapy protein structure protozoal infection scanning electron microscopy trypanosomiasis

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英文摘要

Studies on the purification of an anti-trypanosomal factor (ATF- II) from the bacterial species, Pseudomonas fluorescens, were continued. It was necessary to modify the purification procedure used previously in order to obtain pure fractions that were suitable for NMR analysis. As before, we used high-speed countercurrent chromatography (CCC) employing the Ito multilayer coiled column but in the high pressure chromatography system (HPLC) we employed both preparative and analytical carbohydrate analysis columns to obtain the NMR fractions. Work is in progress to obtain sufficient amounts of pure compound for these studies. The determination of chemical structure is essential before studies on synthesis are initiated and pharmacological and toxicological properties are examined employing experimental infections with Trypanosoma cruzi.

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