寄生虫病的生理和细胞化学病理学-猫眼课题宝

寄生虫病的生理和细胞化学病理学

批准号：

4688350

负责人：

T I MERCADO

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/4688350

关键词：

Pseudomonas Trypanosoma cruzi dialysis gel electrophoresis gel filtration chromatography histochemistry /cytochemistry microorganism culture microorganism growth microorganism interaction microorganism metabolism parasitic disease chemotherapy parasitic diseases protozoal infection protozoal toxin scanning electron microscopy

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英文摘要

Studies on an anti-trypanosomal factor from the bacterial species, Pseudomonas fluorescens, disclosed that extraction procedures employing ether and ethanol as well as chromatographic techniques with hydrophobic columns were very effective for the purification of the lytic substance. The elucidation of the hydrophobic and hydrophylic components will be the subject of further studies on the chemical structure of this compound. The aim of the project is to synthesize the active factor, examine its chemotherapeutic potential in experimental infections with Trypanosoma cruzi, and determine its mechanism of action.

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