THE HEART IN TANGIER DISEASE

丹吉尔疾病中的心脏

• 批准号: 3843423
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843423
• 关键词: Schwann cells; Tangier disease; aorta; atherosclerotic plaque; cholesterol; coronary artery; coronary bypass; coronary disorder; electron microscopy; fibroblasts; heart valve disorder; high density lipoproteins; histopathology; human tissue; light microscopy; low density lipoprotein; optical polarization; postmortem; stainings

Cardiac necropsy findings are described in a 72-year-old man with Tangier disease whose plasma total cholesterol levels averaged 70 mg/dl, low- density lipoprotein cholesterol 45 mg/dl, and high-density lipoprotein cholesterol 1.4 mg/dl, and who had coronary artery bypass grafting for severe atherosclerotic coronary artery disease. At necropsy, 24 (33%) of the 72 five-mm segments of the 4 major (right, left main, left anterior descending and left circumflex) native coronary arteries and 4 (15%) of the 27 five-mm segments of the saphenous vein aorto-coronary bypass conduits were narrowed greater than 75% in cross-sectional area by atherosclerotic plaques. The plaques were composed primarily (91-97%) of fibrous tissue. Oil red O staining, polarized light microscopy, and electron microscopy showed the presence of cholesterol deposits in the plaques and in the walls of coronary arteries, saphenous vein grafts and aorta. Such deposits also were found in foam cells of histiocytic origin, fibroblasts in all 4 cardiac valves and in Schwann cells of cardiac nerves.

心脏尸检结果描述在一个72岁的丹吉尔男子