STUDIES OF CENTRAL NERVOUS SYSTEM FUNCTIONAL ANATOMY

中枢神经系统功能解剖学研究

• 批准号: 3845197
• 负责人: M HERKENHAM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3845197
• 关键词: Cannabis; antidepressants; autoradiography; brain mapping; cannabinoids; cocaine; corticosteroid receptors; corticotropin releasing factor; dopamine; drug receptors; enzyme biosynthesis; human tissue; in situ hybridization; mood disorders; neuroendocrine system; neuropeptides; neurotransmitter receptor; psychosis; stress

This Section combines molecular and neuroanatomical methods to reveal dynamic CNS events that relate to issues of mental health and drug abuse. Mapping drug and neuro-transmitter receptors using autoradiography has provided important basic information about brain organization and function. The cannabinoid receptor has been localized to specific neuronal elements in brain, and we examined its relationship to the dopamine system and to "reward" pathways. In situ hybridization histochemistry is used to examine the regulation of gene expression of neuropeptides, monoamine transporters and synthe-sizing enzymes, and adrenal steroid receptors. Studies are designed to elucidate brain mechanisms involved in stress and chronic antidepressant drug treatment, with a focus on the role of corticotropin releasing hormone in the pathophysiology of affective disorders. Other studies examine CNS adaptive changes caused by drugs of abuse, such as marijuana and cocaine.

本节结合分子和神经解剖学方法，揭示 与精神健康和药物滥用问题相关的动态CNS事件。 利用放射自显影术绘制药物和神经递质受体， 提供了关于大脑组织的重要基本信息， 功能 大麻素受体定位于特定的 神经元元素在大脑中，我们研究了它的关系， 多巴胺系统和“奖励”途径。 原位杂交 组织化学用于检查基因表达的调节， 神经肽、单胺转运蛋白和合成酶，以及 肾上腺类固醇受体 研究旨在阐明大脑 参与应激和慢性抗抑郁药物治疗的机制， 重点是促肾上腺皮质激素释放激素在 情感障碍的病理生理学 其他研究检查CNS 由滥用药物引起的适应性变化，如大麻和可卡因。