STUDIES OF CENTRAL NERVOUS SYSTEM FUNCTIONAL ANATOMY

中枢神经系统功能解剖学研究

• 批准号: 3901006
• 负责人: M HERKENHAM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3901006
• 关键词: Primates; autoradiography; brain mapping; cannabinoids; central nervous system; corticosteroids; disease /disorder model; drug receptors; drug withdrawal; enzyme biosynthesis; gene expression; in situ hybridization; laboratory rat; mental disorders; neuroanatomy; neuroendocrine system; neuropeptides; neuropharmacology; neurophysiology; neuropsychology; physiologic stressor; prostaglandin receptor; stress; tranquilizer

Our work can be divided into five major categories: neuroanatomy, neuropharmacology, molecular neuroendocrinology, physiology, and behavior. Mapping receptor localizations using the in vitro binding and autoradiography techniques yields important basic information about brain organization and function. We have localized the cannabinoid receptor in brain. The molecular biology group uses in situ hybridization to examine the regulation of gene expression of neuropeptides, monoamine synthesizing enzymes, and adrenal steroid receptors, which have been implicated from clinical studies in the pathophysiology of psychiatric disorders. Behavioral studies are designed to assess a variety of factors associated with anti-anxiety drug withdrawal determinants of drug response, Maudsley rats, taste aversion learning, kindling, stress-related CNS changes, and central administration and monitoring of neuroendocrine factors in primates.

我们的工作可以分为五大类：神经解剖学， 神经药理学、分子神经内分泌学、生理学和行为学。 使用体外结合和标记受体定位 放射自显影技术提供有关大脑的重要基本信息 组织和职能。我们已经将大麻素受体定位在 大脑。分子生物学小组使用原位杂交技术来检测 神经肽基因表达调控、单胺合成 酶和肾上腺类固醇受体，它们被认为与 精神疾病病理生理学的临床研究。 行为研究旨在评估与之相关的各种因素 随着抗焦虑药物戒断的药物反应决定因素，莫德斯利 大鼠，味觉厌恶学习，点燃，应激相关的中枢神经系统变化，以及 神经内分泌因子的中央管理和监测 灵长类动物。