STUDIES OF CENTRAL NERVOUS SYSTEM FUNCTIONAL ANATOMY

中枢神经系统功能解剖学研究

• 批准号: 3922054
• 负责人: M HERKENHAM
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3922054
• 关键词: Primates; autoradiography; brain mapping; central nervous system; disease /disorder model; drug withdrawal; laboratory rat; mental disorders; neuroanatomy; neuroendocrine system; neuropeptide receptor; neuropeptides; neuropharmacology; neurophysiology; stress; tranquilizer

Our work can be divided into six major categories: neuroanatomy, neuropharmacology, neuroendocrinology, molecular biology, physiology, biology, physiology, and behavior. Mapping receptor localizations using the in vitro binding and autoradiography techniques yields important basic information about brain organization and function. The molecular biology group examines the regulation of specific genes for neuropeptides and monoamine synthesizing enzymes which have been implicated from clinical studies in the pathophysiology of psychiatric disorders and provides hypotheses based on findings from animal models which could be tested in patients. Similarly, the endocrinology effort addresses animal models of stress and the roles of peripheral hormones in CNS function. Physiological studies have examined regulation of opiate receptors in the neurohypophysis. Behavioral studies are designed to assess a variety of factors associated with anti-anxiety drug withdrawal, determinants of drug response, Maudsley rats, taste aversion learning, kindling, stress-related CNS changes, and central administration and monitoring of neuroendocrine factors in primates.

我们的工作可以分为六大类：神经解剖学， 神经药理学，神经内分泌学，分子生物学， 生理学，生物学，生理学和行为学。 映射受体 使用体外结合和放射自显影进行定位 技术产生了关于大脑的重要基本信息 组织和功能。 分子生物学小组研究了 神经肽和单胺特异性基因调控 合成酶，这些酶与临床 精神疾病的病理生理学研究， 提供了基于动物模型发现的假设， 可以在患者身上进行测试。 同样，内分泌学的努力 解决动物模型的压力和周边的作用， 中枢神经系统功能的激素。 生理学研究已经检验了 神经垂体中阿片受体的调节。 行为 研究旨在评估与以下因素相关的各种因素 抗焦虑药物戒断，药物反应的决定因素， Maudsley大鼠，味觉厌恶学习，点燃，应激相关 CNS变化，以及中枢给药和监测 神经内分泌因子